この研究は、ヒト乳がん細胞株MCF-7に、携帯電話またはWi-Fi 装置を用いて電磁界ばく露（1時間）を与え、続いてカプサイシン（CAP）刺激を与え、細胞のTRPV1チャネルを介したアポトーシス、酸化ストレスなどを測定した。TRPV1はCAP依存性のカルシウムイオン透過性チャネルである。携帯電話またはWi-Fi 装置と細胞との、10、20、25cmとした。その結果、距離0、1、5cmのばく露群では､対照群に比べ、細胞の活性化酸素種産生、カルシウムイオン濃度、アポトーシスなどが高かった；20、25cmでは、対照群と有意差がなかった､と報告している。
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The effects of exposure of human breast cancer cells to a 900, 1800 or 2450 MHz electromagnetic field on apoptosis, oxidative stress and the cytosolic Ca2+ concentration should be investigated at different distances to the field source.
The cells were divided into 4 groups: 1) control group, exposure to an electromagnetic field of 2) 900 MHz, 3) 1800 MHz and 4) 2450 MHz. In groups 2-4 cells were exposed at distances of 0 cm, 1 cm, 5 cm, 10 cm, 20 cm and 25 cm to the exposure source, respectively. Each exposure at each distance was repeated 4-6 times.
unit of SAR values not clear (mW/kg or W/kg) - contradictory specifications in text and table 1 and exposure setup and specifications for exposure to 1800 MHz and 2450 MHz fields (fields 2 and 3) not clear
| 周波数 | 900 MHz |
|---|---|
| タイプ |
|
| ばく露時間 | continuous for 1 hour |
| Modulation type | pulsed |
|---|---|
| Repetition frequency | 217 Hz |
| ばく露の発生源／構造 |
|
|---|---|
| チャンバの詳細 | cells were kept in a circulatory water bath in falcon tubes (6 tubes at a time) |
| ばく露装置の詳細 | the exposure system was located in a special room that was fitted with plastic furniture to minimize the possibility of radiation reflection; the walls of the room were covered by chromium-nickel sheets (thickness: 1 mm) to protect the cells against possible external electromagnetic interference; falcon tubes were placed on a plexi glas table; distance was arranged at 0 cm, 1 cm, 5 cm, 10 cm, 20 cm and 25 cm between the falcon tubes and the antenna; temperature in room and flasks was maintained at 37°C and humidity of 83% |
| 周波数 | 1,800 MHz |
|---|---|
| タイプ |
|
| ばく露時間 | continuous for 1 hour |
| ばく露の発生源／構造 |
|
|---|---|
| ばく露装置の詳細 | distance was arranged at 0 cm, 1 cm, 5 cm, 10 cm, 20 cm and 25 cm between cells and the antenna |
No parameters are specified for this exposure.
| 周波数 | 2,450 MHz |
|---|---|
| タイプ |
|
| ばく露時間 | continuous for 1 hour |
| ばく露の発生源／構造 |
|
|---|---|
| ばく露装置の詳細 | distance was arranged at 0 cm, 1 cm, 5 cm, 10 cm, 20 cm and 25 cm between cells and the antenna |
No parameters are specified for this exposure.
In all exposure groups (2-4), the cytosolic Ca2+ concentration was significantly increased in samples with a distance of 0-5 cm to the field source compared to the control group.
Cell viability was significantly reduced in group 2 (900 MHz) and 4 (2450 MHz) at distances of 0-5 cm and in group 3 (1800 MHz) at distances of 0-25 cm compared to the control group.
The generation of reactive oxygen species was significantly increased in all exposure groups in samples with a distance of 0-5 cm to the field source in comparison to the control group.
Apoptosis was significantly increased in groups 2 and 3 at distances of 0-10 cm and in group 4 at 0-5 cm compared to the control group.
The enzyme activities of caspase-3 and -9 were significantly increased in all exposure groups in samples with a distance of 0-5 cm to the field source when compared to the control group.
The authors conclude that exposure of human breast cancer cells to 900, 1800 and 2450 MHz electromagnetic fields might increase apoptosis, oxidative stress and the cytosolic Ca2+ concentration at distances of up to 10 cm to the source of the field. Thus, a safety distance of 10 cm to such exposure sources could mean an effective protection against these effects and an administration of TRPV1 ion channel blockers might be a sensible therapeutic approach for their treatment.
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