Study type: Medical/biological study (experimental study)

Effects of olive leave extract on metabolic disorders and oxidative stress induced by 2.45 GHz WIFI signals. med./bio.

Published in: Environ Toxicol Pharmacol 2013; 36 (3): 826-834

Aim of study (acc. to author)

To examine the effects of olive leave extracts on oxidative stress and glucose metabolism in liver and kidney of rats exposed to a 2.45 GHz electromagnetic field.

Background/further details

Four groups of rats were examined (n=6 per group): 1.) sham exposure group, daily injection of saline solution, 2.) sham exposure group, daily injection of olive leave extract (100 mg/kg body weight), 3.) exposure group, daily injection of saline solution and 4.) exposure group, daily injection of olive leave extract (100 mg/kg body weight).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.45 GHz
Exposure duration: 1 hour/day for 21 consecutive days
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Exposure 1

Main characteristics
Frequency 2.45 GHz
Type
Exposure duration 1 hour/day for 21 consecutive days
Exposure setup
Exposure source
  • WiFi device (D-Link DWL-3200AP)
Setup animal cages were placed under the access point of the WiFi-Device with two integrated omnidirectional antennas
Sham exposure A sham exposure was conducted.
Additional info control rats were placed under the same condition without the field
Parameters

No parameters are specified for this exposure.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:

Main outcome of study (acc. to author)

In the liver and kidneys of exposed rats the enzyme activities of all superoxide dismutases, catalase and glutathione peroxidase as well as the level of thiol groups were significantly decreased compared to the sham exposed rats, while an administration of olive leave extract prevented these effects. Additionally, the lipid peroxidation was significantly increased in the liver and the kidneys of exposed rats in comparison to the control group. An administration of olive leave extract led to a signifcant decrease of the lipid peroxidation in the liver of exposed rats (but not in the kidneys) compared to exposed rats without olive leave extract.
Histopathological examinations of the liver of exposed rats revealed morphological abnormalities (e.g. hypertrophy, cell shape, steatosis) compared to the control group, while administration of olive leave extract prevented these effects.
The exposure of rats induced a diabetes-like status. In the exposure group, 20 minutes after the injection of glucose solution, blood glucose levels were significantly higher than in the sham exposure group, while administration of olive leave extract prevented the exposure related effect.
After exposure, various plasma parameters were changed compared to the control group: The level of total proteins, triglycerides, alanine transaminase, aspartate aminotransferase and creatinine was significantly increased while the level of uric acid was significantly decreased. In the exposure group with olive leave extract administration, the values for total proteins and creatinine were significantly reduced compared to the exposure group without olive leaf extract, while the level of uric acid was significantly increased.
The authors conclude that exposure to a 2.45 GHz signal could induce oxidative stress and a diabetes-like status in rats, while olive leave extract could attenuate these effects.

Study character:

Study funded by

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