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Medical/biological study (experimental study)

Modulation of wireless (2.45 GHz)-induced oxidative toxicity in laryngotracheal mucosa of rat by melatonin.

Published in: Eur Arch Otorhinolaryngol 2013; 270 (5): 1695-1700

Aim of study (acc. to author)

To investigate the possible protective role of melatonin on oxidative stress generated by exposure to a WiFi-signal in rats.
Background/further details: Four groups (n=8 per group) were examined: 1.) cage control, 2.) sham exposure + saline injection. 3.) exposure and 4.) exposure + melatonin injection.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2,450 MHz
Modulation type: pulsed
Exposure duration: continuous for 60 min/d for 30 days (28 days? different indications in the article)
Exposure 1
Main characteristics
Frequency 2,450 MHz
Type
Waveform
Exposure duration continuous for 60 min/d for 30 days (28 days? different indications in the article)
Modulation
Modulation type pulsed
Repetition frequency 217 Hz
Exposure setup
Exposure source
  • half-wave dipole or monopole (varying indications within the text; remark EMF-Portal)
Distance between exposed object and exposure source 1 m
Chamber exposure system was organized with a special cylindrical strainer which is appropriate for exposure condition and physical size of one rat (length 15 cm, diameter 5 cm), noses of rats were positioned in close contact to the antenna (according to a table in the article: distance between head and antenna 1 m (?)) and the tube was ventilated from head to tail to decrease stress, 8 rats (Figure shows 6 rats (?)) exposed at the same time
Setup whole exposure system was kept in a Faraday cage
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
electric field strength 11.07 V/m effective value measured - closest point to body
SAR 0.143 W/kg effective value calculated whole body -
SAR 4.2 W/kg maximum calculated - -
Reference articles
  • Gumral N et al. (2009): Effects of Selenium and L-Carnitine on Oxidative Stress in Blood of Rat Induced by 2.45-GHz Radiation from Wireless Devices.
Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated material:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

In the exposed group, the amount of lipid peroxidation was significantly increased compared to the cage control and the sham exposed group, while an administration of melatonin prevented this effect. No differences in the level of reduced glutathione were found between the groups. The enzyme activity of the glutathione peroxidase was lower (not significantly) in the exposed group than in the cage control and the sham exposure group. However, in the exposure group with melatonin administration, the enzyme activity of the glutathione peroxidase was significantly increased compared to the exposure group without melatonin administration.
Study character:

Study funded by

  • not stated/no funding

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