研究のタイプ: 医学/生物学の研究 (experimental study)

[2.45 GHzWi-Fi信号によって生じた代謝異常および酸化ストレスに対するオリーブの葉の抽出物の作用] med./bio.

Effects of olive leave extract on metabolic disorders and oxidative stress induced by 2.45 GHz WIFI signals.

掲載誌: Environ Toxicol Pharmacol 2013; 36 (3): 826-834

この研究は、ラットを2.45GHzWi-Fi信号(RF)にばく露し、生じた影響およびその影響に対するオリーブ葉抽出物(OLE)の防護的作用の有無を調べた。Wister系雄ラット24匹を6匹ずつの4群に分けた;対照群RF擬似ばく露、生食液の腹腔内注射)、OLE群(RF擬似ばく露、OLEの腹腔内注射)、RF群(RFばく露、生食液の腹腔内注射RF+OLE群(RFばく露、OLEの腹腔内注射)。RFばく露は、ラットを入れたケージをWiFi装置(2.45GHz)のアクセスポイントの下に置いて行ったと記されている(擬似ばく露時にはWiFi装置の電源オフ)。ばく露時間は1日1時間で、21日連続した。その結果、RF群では、糖尿病状態が誘導された;肝臓腎臓グルタチオンペルオキシダーゼ(GPx)、カタラーゼ(CAT)、スーパーオキシドジスムターゼ(SOD)の活性およびチオール基量が低下した;肝臓腎臓マロンジアルデヒドMDA)濃度が上昇した;RF+OLE群では、グルコース代謝異常はなく、肝臓腎臓のGPx、CAT、SOD活性およびチオール基量も変化がなかった;また、肝臓のMDA濃度上昇は抑制されたが、腎臓では上昇した、などを報告している。

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研究目的(著者による)

To examine the effects of olive leave extracts on oxidative stress and glucose metabolism in liver and kidney of rats exposed to a 2.45 GHz electromagnetic field.

詳細情報

Four groups of rats were examined (n=6 per group): 1.) sham exposure group, daily injection of saline solution, 2.) sham exposure group, daily injection of olive leave extract (100 mg/kg body weight), 3.) exposure group, daily injection of saline solution and 4.) exposure group, daily injection of olive leave extract (100 mg/kg body weight).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.45 GHz
ばく露時間: 1 hour/day for 21 consecutive days
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ばく露1

主たる特性
周波数 2.45 GHz
タイプ
  • electromagnetic field
ばく露時間 1 hour/day for 21 consecutive days
ばく露装置
ばく露の発生源/構造
  • WiFi device (D-Link DWL-3200AP)
ばく露装置の詳細 animal cages were placed under the access point of the WiFi-Device with two integrated omnidirectional antennas
Sham exposure A sham exposure was conducted.
Additional information control rats were placed under the same condition without the field
パラメータ

No parameters are specified for this exposure.

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:

研究の主なアウトカム(著者による)

In the liver and kidneys of exposed rats the enzyme activities of all superoxide dismutases, catalase and glutathione peroxidase as well as the level of thiol groups were significantly decreased compared to the sham exposed rats, while an administration of olive leave extract prevented these effects. Additionally, the lipid peroxidation was significantly increased in the liver and the kidneys of exposed rats in comparison to the control group. An administration of olive leave extract led to a signifcant decrease of the lipid peroxidation in the liver of exposed rats (but not in the kidneys) compared to exposed rats without olive leave extract.
Histopathological examinations of the liver of exposed rats revealed morphological abnormalities (e.g. hypertrophy, cell shape, steatosis) compared to the control group, while administration of olive leave extract prevented these effects.
The exposure of rats induced a diabetes-like status. In the exposure group, 20 minutes after the injection of glucose solution, blood glucose levels were significantly higher than in the sham exposure group, while administration of olive leave extract prevented the exposure related effect.
After exposure, various plasma parameters were changed compared to the control group: The level of total proteins, triglycerides, alanine transaminase, aspartate aminotransferase and creatinine was significantly increased while the level of uric acid was significantly decreased. In the exposure group with olive leave extract administration, the values for total proteins and creatinine were significantly reduced compared to the exposure group without olive leaf extract, while the level of uric acid was significantly increased.
The authors conclude that exposure to a 2.45 GHz signal could induce oxidative stress and a diabetes-like status in rats, while olive leave extract could attenuate these effects.

研究の種別:

研究助成

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