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To examine the effects of olive leave extracts on oxidative stress and glucose metabolism in liver and kidney of rats exposed to a 2.45 GHz electromagnetic field.
Four groups of rats were examined (n=6 per group): 1.) sham exposure group, daily injection of saline solution, 2.) sham exposure group, daily injection of olive leave extract (100 mg/kg body weight), 3.) exposure group, daily injection of saline solution and 4.) exposure group, daily injection of olive leave extract (100 mg/kg body weight).
ばく露時間: 1 hour/day for 21 consecutive days
|ばく露時間||1 hour/day for 21 consecutive days|
No parameters are specified for this exposure.
In the liver and kidneys of exposed rats the enzyme activities of all superoxide dismutases, catalase and glutathione peroxidase as well as the level of thiol groups were significantly decreased compared to the sham exposed rats, while an administration of olive leave extract prevented these effects. Additionally, the lipid peroxidation was significantly increased in the liver and the kidneys of exposed rats in comparison to the control group. An administration of olive leave extract led to a signifcant decrease of the lipid peroxidation in the liver of exposed rats (but not in the kidneys) compared to exposed rats without olive leave extract.
Histopathological examinations of the liver of exposed rats revealed morphological abnormalities (e.g. hypertrophy, cell shape, steatosis) compared to the control group, while administration of olive leave extract prevented these effects.
The exposure of rats induced a diabetes-like status. In the exposure group, 20 minutes after the injection of glucose solution, blood glucose levels were significantly higher than in the sham exposure group, while administration of olive leave extract prevented the exposure related effect.
After exposure, various plasma parameters were changed compared to the control group: The level of total proteins, triglycerides, alanine transaminase, aspartate aminotransferase and creatinine was significantly increased while the level of uric acid was significantly decreased. In the exposure group with olive leave extract administration, the values for total proteins and creatinine were significantly reduced compared to the exposure group without olive leaf extract, while the level of uric acid was significantly increased.
The authors conclude that exposure to a 2.45 GHz signal could induce oxidative stress and a diabetes-like status in rats, while olive leave extract could attenuate these effects.