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To determine the effects of microwaves on the brain lipid peroxidation system (in hippocampus and cortex), and the possible protective effects of melatonin on brain degeneration induced by microwaves.
Male rats were divided into three groups: 1) sham-exposed control group (n = 8); 2) 900 MHz microwave exposed group (n = 8), and 3) 900 MHz microwave exposed + melatonin group (100 µg/kg before daily exposure) (n = 10).
|ばく露時間||repeated daily exposure, 30 min/day, 5 days/week, for 2 weeks|
|Repetition frequency||217 Hz|
|チャンバの詳細||A special exposure device with five antennas for insulated exposure was used.|
|ばく露装置の詳細||Rats were restrained in ventilated plastic tube cages (12 cm long, 5.5 cm in diameter) with their heads positioned in close contact above the dipole antenna.|
|Sham exposure||A sham exposure was conducted.|
|Additional information||Sham and RF only exposed rats were injected s.c. with an equal volume of isotonic saline solution instead of MEL.|
The levels of lipid peroxidation in the cortex and hippocampus increased in the exposed group compared with the control group, although the levels in the hippocampus were decreased by "microwave+melatonin" administration. The cortex lipid peroxidation levels were unaffected by melatonin treatment.
The authors conclude that melatonin may prevent microwave-induced oxidative changes in the hippocampus by strengthening the antioxidant defense.