研究のタイプ: 医学/生物学の研究 (experimental study)

[900 MHzの携帯電話によって誘導される腎臓における酸化的防護:メラトニンによる防護] med./bio.

Oxidative damage in the kidney induced by 900-MHz-emitted mobile phone: protection by melatonin.

掲載誌: Arch Med Res 2005; 36 (4): 350-355

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研究目的(著者による)

To examine 900 MHz mobile phone-induced oxidative stress that promotes production of reactive oxygen species (ROS) on renal tubular damage and the role of melatonin (a potent free radical scavenger and antioxidant agent) on kidney tissue against possible oxidative damage.

詳細情報

Melatonin was injected daily at 17 h with a dose of 100 µg/kg (before exposure).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: CW
ばく露時間: repeated daily exposure, 30 min/day for 10 days

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
ばく露時間 repeated daily exposure, 30 min/day for 10 days
Modulation
Modulation type CW
ばく露装置
ばく露の発生源/構造
チャンバの詳細 The exposure system consisted of a ventilated plastic tube cage (12 cm long x 5.5 cm in diameter) and a dipole antenna.
ばく露装置の詳細 The whole body of the rat was positioned in close contact above the antenna.
Additional information Animals were allocated to three groups: sham exposed, EMR exposed, and EMR exposed + melatonin treated. Melatonin dissolved in ethanol/saline was injected s.c. daily immediately before exposure. Sham exposed rats received isotonic saline solution instead. Rats were anesthetized with sodium pentobarbital.
パラメータ
測定量 種別 Method Mass 備考
電力 2 W peak - - -
電力密度 1.04 mW/cm² mean 測定値 - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
  • kidney
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

In the exposed group, while tissue malondialdehyde and urine N-acetyl-beta-d-glucosaminidase levels increased, superoxide dismutase, catalase, and glutathione peroxidase activities were reduced. Melatonin treatment reversed these effects as well.
These data demonstrated the role of oxidative mechanism induced by 900 MHz mobile phone exposure, and melatonin, via its free radical scavenger and antioxidant properties, ameliorated oxidative tissue injury in rat kidney. These results show that melatonin may exhibit a protective effect on mobile phone-induced renal impairment.

研究の種別:

研究助成

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