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To examine 900 MHz mobile phone-induced oxidative stress that promotes production of reactive oxygen species (ROS) on renal tubular damage and the role of melatonin (a potent free radical scavenger and antioxidant agent) on kidney tissue against possible oxidative damage.
Melatonin was injected daily at 17 h with a dose of 100 µg/kg (before exposure).
|ばく露時間||repeated daily exposure, 30 min/day for 10 days|
|チャンバの詳細||The exposure system consisted of a ventilated plastic tube cage (12 cm long x 5.5 cm in diameter) and a dipole antenna.|
|ばく露装置の詳細||The whole body of the rat was positioned in close contact above the antenna.|
|Additional information||Animals were allocated to three groups: sham exposed, EMR exposed, and EMR exposed + melatonin treated. Melatonin dissolved in ethanol/saline was injected s.c. daily immediately before exposure. Sham exposed rats received isotonic saline solution instead. Rats were anesthetized with sodium pentobarbital.|
In the exposed group, while tissue malondialdehyde and urine N-acetyl-beta-d-glucosaminidase levels increased, superoxide dismutase, catalase, and glutathione peroxidase activities were reduced. Melatonin treatment reversed these effects as well.
These data demonstrated the role of oxidative mechanism induced by 900 MHz mobile phone exposure, and melatonin, via its free radical scavenger and antioxidant properties, ameliorated oxidative tissue injury in rat kidney. These results show that melatonin may exhibit a protective effect on mobile phone-induced renal impairment.