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To study the intensity of oxidative stress in the brain of animals chronically exposed to cell phones and potential protective effects of melatonin in reducing oxidative stress and brain injury.
Experiments were performed on 84 adult male rats exposed to microwave irradiation during 20, 40 and 60 days (4 hours/day during light period). Four groups (each 21 animals) were formed: 1) control-rats treated daily by saline, 2) rats treated daily with melatonin (2 mg/kg body weight), 3) microwave exposed rats and 4) microwave exposed rats treated with melatonin (2 mg/kg body weight).
|ばく露時間||repeated daily exposure, 4 h/day, for 20, 40, and 60 days|
|チャンバの詳細||Seven animals were housed and exposed collectively in pure polycarbonate cages of 30 Œ 40 Œ 40 cm (W Œ L Œ H).|
|ばく露装置の詳細||Every four hours, two cages from the MW and MW+Mel groups were transferred to a wooden desk with rubber surface placed at 5 m from the housed rats, and a mobile test phone was put in a small perforated polycarbonate cell in the center of each cage preventing damage caused by rats.|
|Sham exposure||A sham exposure was conducted.|
|Additional information||Two dummy phones were put in the control and Mel group cages at the same time.|
A significant increase in the brain tissue malondialdehyde and carbonyl group concentration was registered during the whole exposure. Decreased enzyme activity of catalase and increased activity of xanthine oxidase remained after 40 and 60 days of exposure to mobile phones. Melatonin treatment significantly prevented the increase in the malondialdehyde content and xantine oxidase activity in the brain after 40 days of exposure while it was unable to prevent the decrease of catalase activity and increase of carbonyl group contents.
Mobile phones caused oxidative damage biochemically by increasing the levels of malondialdehyde, carbonyl groups, xanthine oxidase and decreasing catalase enzyme activity. Treatment with the melatonin significantly prevented oxidative damage in the brain.