研究のタイプ: 医学/生物学の研究 (experimental study)

[メラトニンは携帯電話のマイクロ波放射への慢性ばく露によりラット脳に誘発された酸化ストレスを減少させる。] med./bio.

Melatonin reduces oxidative stress induced by chronic exposure of microwave radiation from mobile phones in rat brain.

掲載誌: J Radiat Res 2008; 49 (6): 579-586

この研究は、携帯電話慢性的にばく露されたラットの脳における酸化ストレスの強さを評価し、メラトニン酸化ストレスおよび脳損傷を減少させる保護的効果の可能性があるか否かを調べた。携帯電話のテスト機(SAR=0.043-0.135W/kg)を用いて、Wisterラットに20、40、60日間のばく露実験を行った。各実験は、対照群(生食投与群)、メラトニン投与(Mel)群、マイクロ波ばく露MW)群、MW+Mel群の4群で行った。その結果、MWばく露群では、MDAおよびカルボニル基群の著しい増加がみられ、40、60日ばく露後には、CATの減少とXOの活性増加が見られた;メラトニン処置は40日ばく露後のMDAレベルとXO活性の増加を阻害したが、CATの減少とカルボニル基群の増加を阻害することはできなかった、と報告している。

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研究目的(著者による)

To study the intensity of oxidative stress in the brain of animals chronically exposed to cell phones and potential protective effects of melatonin in reducing oxidative stress and brain injury.

詳細情報

Experiments were performed on 84 adult male rats exposed to microwave irradiation during 20, 40 and 60 days (4 hours/day during light period). Four groups (each 21 animals) were formed: 1) control-rats treated daily by saline, 2) rats treated daily with melatonin (2 mg/kg body weight), 3) microwave exposed rats and 4) microwave exposed rats treated with melatonin (2 mg/kg body weight).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: CW
ばく露時間: repeated daily exposure, 4 h/day, for 20, 40, and 60 days
  • 電界強度: 18.356 V/m (9.88-18.356 V/m)
  • 磁束密度: 8.69 µT (4.68-8.69 µT)
  • SAR: 0.135 W/kg average over mass (whole body) (0.043-0.135 W/kg)

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
特性
  • near field
ばく露時間 repeated daily exposure, 4 h/day, for 20, 40, and 60 days
Modulation
Modulation type CW
ばく露装置
ばく露の発生源/構造
  • セルラ-電話
  • connected to a communication tester
チャンバの詳細 Seven animals were housed and exposed collectively in pure polycarbonate cages of 30 Œ 40 Œ 40 cm (W Œ L Œ H).
ばく露装置の詳細 Every four hours, two cages from the MW and MW+Mel groups were transferred to a wooden desk with rubber surface placed at 5 m from the housed rats, and a mobile test phone was put in a small perforated polycarbonate cell in the center of each cage preventing damage caused by rats.
Sham exposure A sham exposure was conducted.
Additional information Two dummy phones were put in the control and Mel group cages at the same time.
パラメータ
測定量 種別 Method Mass 備考
電界強度 18.356 V/m - 測定値 - 9.88-18.356 V/m
磁束密度 8.69 µT - 測定値 - 4.68-8.69 µT
SAR 0.135 W/kg average over mass 計算値 whole body 0.043-0.135 W/kg

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

A significant increase in the brain tissue malondialdehyde and carbonyl group concentration was registered during the whole exposure. Decreased enzyme activity of catalase and increased activity of xanthine oxidase remained after 40 and 60 days of exposure to mobile phones. Melatonin treatment significantly prevented the increase in the malondialdehyde content and xantine oxidase activity in the brain after 40 days of exposure while it was unable to prevent the decrease of catalase activity and increase of carbonyl group contents.
Mobile phones caused oxidative damage biochemically by increasing the levels of malondialdehyde, carbonyl groups, xanthine oxidase and decreasing catalase enzyme activity. Treatment with the melatonin significantly prevented oxidative damage in the brain.

研究の種別:

研究助成

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