研究のタイプ: 医学/生物学の研究 (observational study)

[インドのコインバトールの人口集団において職業的な低周波電磁界(EMF)ばく露を受けた電気労働者での染色体の変化の評価] med./bio.

Evaluation of chromosomal alteration in electrical workers occupationally exposed to low frequency of electro magnetic field (EMFs) in Coimbatore population, India.

掲載誌: Asian Pac J Cancer Prev 2012; 13 (6): 2961-2966

この研究は、コインバトール地区およびその周辺地域(南インド、タミルナードゥ州)で、職業的な電磁界ばく露がある電気作業員を対象に、細胞遺伝学的影響の可能性を評価した。ばく露群50人と対照群20人が調査に参加した。ばく露群は、変圧器電力線電気作業員で構成される直接ばく露群(n = 28)と、変電所に隣接する事務所作業員で構成される間接ばく露群の2つのサブグループに分けられた。また参加者は、年齢に応じて、40歳以下群(n = 37)および40歳超え群(n = 33)に分けられた。参加者の末梢リンパ球での染色体損傷の評価には、従来の中期染色体異常(CA)分析と小核MNアッセイを用いた。その結果、ばく露群では、対照群に比べ、CAおよびMNの発生率が高かった;CAの発生率は、長期ばく露群で有意に上昇した;さらに、年齢上昇に伴うCAとMNの増加傾向は、ばく露群および対照群の両方で観察されたが、ばく露群での増加は対照群に比べ有意に大きかった、と報告している。

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研究目的(著者による)

To study the possible cytogenetic effects of electricity workers in Coimbatore District and surrounding region (Tamil Nadu, South India) exposed to electric and magnetic fields.

詳細情報

70 subjects participated including 50 exposed and 20 controls. The exposed group was divided into two subgroups: The "direct exposure group" (n=28) included electrical employees in transformers and power lines and the "indirect exposure group" (n=22) included office workers in place adjacent to electric supply substations. Additionally, the subjects were divided into two groups according to their age (≤ 40 years (n=37) and >40 (n=33)).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50–60 Hz
ばく露時間: from 20 ± 4.7 (direct exposure group) up to 23 ± 6 years (indirect exposure group)
  • 電界強度: 130 V/m minimum (at the surroundings of power generation and transmission systems)
  • 電界強度: 8,310 V/m maximum (at the surroundings of power generation and transmission systems)
  • 電界強度: 300 V/m minimum (inside of power generation and transmission systems)
  • 電界強度: 15,000 V/m maximum (inside of power generation and transmission systems)
  • 磁界強度: 0.5 A/m minimum (around the transformer buildings)
  • 磁界強度: 1.7 A/m maximum (around the transformer buildings)
  • 磁界強度: 0.25 A/m minimum (inside the transformer buildings)
  • 磁界強度: 17 A/m maximum (inside the transformer buildings)

ばく露1

主たる特性
周波数 50–60 Hz
タイプ
  • electric field
  • magnetic field
ばく露時間 from 20 ± 4.7 (direct exposure group) up to 23 ± 6 years (indirect exposure group)
ばく露装置
ばく露の発生源/構造
  • power transmission lines (180-420 kV) and transformers
パラメータ
測定量 種別 Method Mass 備考
電界強度 130 V/m minimum 測定値 - at the surroundings of power generation and transmission systems
電界強度 8,310 V/m maximum 測定値 - at the surroundings of power generation and transmission systems
電界強度 300 V/m minimum 測定値 - inside of power generation and transmission systems
電界強度 15,000 V/m maximum 測定値 - inside of power generation and transmission systems
磁界強度 0.5 A/m minimum 測定値 - around the transformer buildings
磁界強度 1.7 A/m maximum 測定値 - around the transformer buildings
磁界強度 0.25 A/m minimum 測定値 - inside the transformer buildings
磁界強度 17 A/m maximum 測定値 - inside the transformer buildings

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

A higher degree of chromosome aberrations and micronuclei formation was found in exposed subjects compared to controls and the frequency of chromosome aberrations was significantly enhanced with long years of exposure. Moreover, an increase in chromosome aberration and micronuclei formation with age was observed in both exposed subjects and controls, but it was significantly greater in the exposed one.
The data indicate a significant induction of cytogenetic damage in peripheral lymphocytes of workers occupationally exposed to electric and magnetic fields in electric transformer and distribution stations.

研究の種別:

研究助成

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