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To study the effects of 100 µT and 500 µT extremely low-frequency magnetic fields on levels of beta-amyloid protein, protein carbonyl and malondialdehyde in rat brain. The aim of this study was to illuminate the interaction between biomolecules and extremely low-frequency magnetic fields.
30 rats were divided into 3 groups: 2 exposure groups (100 µT and 500 µT) and 1 sham exposure group (each group n=10).
|ばく露時間||2 h/day for 10 months|
|チャンバの詳細||exposures were carried out in methacrylate cages; rats moved freely in the cages during exposure|
|ばく露装置の詳細||pair of Helmholtz coils of 25 cm diameter in a Faraday cage (130 X 65 x 80 cm), with shielding grounded to protect against stray environmental electrical fields; coils were placed horizontally facing one another, and the distance between coils was 25 cm|
|Sham exposure||A sham exposure was conducted.|
|磁束密度||100 µT||spatial average||測定値||-||-|
Protein carbonyl group and malondialdehyde levels were significantly increased by the exposure to 100 µT and 500 µT extremely low-frequency magnetic fields. However, beta-amyloid protein level was not significantly affected. In conclusion, the data showed that long-term exposure (2 h/day for 10 months) can affect some biological macromolecules such as proteins and lipids.