研究のタイプ: 医学/生物学の研究 (experimental study)

[モンゴルスナネズミの脳での酸化ストレスに対するELF-MFの年齢依存的影響] med./bio.

Age-Dependent Effects of ELF-MF on Oxidative Stress in the Brain of Mongolian Gerbils.

掲載誌: Cell Biochem Biophys 2013; 66 (3): 513-521

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研究目的(著者による)

To study the effects of extremely low frequency magnetic fields on oxidative stress in the brain of adult (3 months old) and middle-aged (10 month old) gerbils.

詳細情報

Groups of four gerbils per cage were used: cage control, sham exposed group and three different exposure groups. The gerbils from sham exposed and exposed groups were subdivided into two groups, one sacrificed on the 7th day (immediately after the exposure) and the other one sacrificed on the 10th day from the beginning of the experiment.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50 Hz
ばく露時間: continuous for 7 days

General information

Animals were exposed at three different magnetic flux densities.

ばく露1

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
波形
  • sinusoidal
ばく露時間 continuous for 7 days
ばく露装置
ばく露の発生源/構造
  • elctromagnet
ばく露装置の詳細 electromagnet with a regular laminated transformer core and a pole diameter of 9.5 cm; gerbils placed in 26 cm x 43 cm x 15 cm polycarbonate cages; two cages with 3-4 gerbils positioned simultaneously near the magnet, one on the left and the other on the right side with a distance between 20 cm and 40 cm
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
磁束密度 8.9 mT maximum 測定値 - on the electromagnetic poles
磁束密度 0.5 mT average over time 測定値 - in the cages
磁束密度 0.25 mT average over time 測定値 - in the cages
磁束密度 0.1 mT average over time 測定値 - in the cages

Reference articles

  • Janac B et al. (2012): [異なる年齢のスナネズミにおける超低周波磁界によって生じた運動行動の変化の時間的なパターン]
  • Nikolic LM et al. (2010): [リンゴマイマイの神経系でのリン酸代謝に対する交流磁界の影響]

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

In all gerbils, extremely low frequency magnetic field exposure significantly increased oxidative stress in all investigated brain regions. This effect increased in a magnetic flux density intensity dependent manner and was higher in middle-aged gerbils. Three days after exposure termination, the values of oxidative stress parameters showed a tendency to return to their control levels, particularly in 3-month-old gerbils.
These findings indicate that an extremely low frequency magnetic field exposure is able to induce oxidative stress in the brain of gerbils in an age- and magnetic field intensity-dependent manner.

研究の種別:

研究助成

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