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In the present study early adolescent mice were used as a model to investigate the potential effects of chronic exposure to extremely low frequency magnetic field during this developmental stage on some aspects of cognitive function.
16 mice were exposed from postnatal days 23-35 to a 50 Hz magnetic field for 60 min/day. On postnatal days 36-45, the potential effects of the magnetic field exposure on spatial memory performance were examined. 17 mice were sham exposed. Only 22 mice (n=11 each group) were used in the Morris water maze task.
ばく露時間: continuous for 60 min/day from postnatal days 23 to 35
|ばく露時間||continuous for 60 min/day from postnatal days 23 to 35|
|ばく露装置の詳細||70 cm x 40 cm x 43 cm plastic frame was wrapped with 4 horizontal layers with 250 turns each, forming a single coil with a 60 cm x 30 cm x 43 cm exposure area inside; mice placed in a 50 cm x 25 cm x 25 cm plastic box in this exposure area; field variation inside the plastic box: ± 4.5 %; exposure system placed in a room with a constant temperature of 30°C|
|Sham exposure||A sham exposure was conducted.|
The data showed that the magnetic field exposure did not affect Y-maze performance, but improved spatial learning acquisition and memory retention in the Morris water maze task (exposed mice learned to locate the platform faster than sham-exposed mice).