研究のタイプ: 医学/生物学の研究 (experimental study)

[携帯電話放射にばく露したボランティアにおけるバイオマーカ] med./bio.

Biomarkers in volunteers exposed to mobile phone radiation.

掲載誌: Toxicol Lett 2015; 235 (2): 140-146

この研究は、先行研究を背景としている。無線周波電磁界血液脳関門BBB)への影響はインビトロあるいは動物での研究がほとんどの中で、1件だけヒトでの研究があり、マイクロ波ばく露による血清トランスサイレンチ(TTR)の有意な上昇を示しているという。研究デザインを改良してこの先行研究の再現を試みた。単ブラインド化無作為化カウンターバランス試験で、健康被験者(n=24:18-30歳)は、3つのばく露条件(10g平均SAR値:2W/kg、0.2W/kg、および擬似ばく露)のマイクロ波(890MHzの携帯電話様の信号)全てのばく露セッションを受けた。それぞれのばく露の前後の血清パラメータを分析した。その結果、マイクロ波ばく露後にフォローアップした2時間以内では、先行研究が報告したマイクロ波ばく露のBBBに対する急性影響は確認されなかった、と報告している。

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研究目的(著者による)

The effects of exposure to a 890 MHz electromagnetic field (GSM) on the human blood brain barrier permeability should be investigated.

詳細情報

The present study should follow up on previous studies by the authors on the human blood brain barrier permeability (Söderqvist et al. 2009a, Söderqvist et al. 2009b, Söderqvist et al. 2009c) using a better study design.
A total of 24 subjects (12 men and 12 women) participated in 3 sessions with at least one week in between. During each session, 1 hour of exposure was conducted in a randomized counter balanced order under the following conditions: 1) exposure with SAR of 2 W/kg, 2) exposure with SAR of 0.2 W/kg, 3) sham exposure. Each participant acted as his or her own control and blood samples were taken: a) at arrival, b) after 30 min of rest, c) after 1 h of rest/start of exposure, d) immediately after exposure, e) 1 h after the end exposure; f) 2 h after the end of exposure.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 890 MHz
Modulation type: pulsed
ばく露時間: continuous for 1 hour
  • SAR: 2 W/kg average over mass (10 g)
ばく露2: 890 MHz
Modulation type: pulsed
ばく露時間: continuous for 1 hour
  • SAR: 0.2 W/kg average over mass (10 g)

ばく露1

主たる特性
周波数 890 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 1 hour
Modulation
Modulation type pulsed
Pulse width 0.577 ms
Repetition frequency 217 Hz
Additional information

signal from GSM test phone; no DTX was used

ばく露装置
ばく露の発生源/構造
  • 基地トランシーバ局
Distance between exposed object and exposure source 4 cm
チャンバの詳細 room was shielded by a specially made baldachin (250 x 210 x 230 cm); inside, special radiofrequency-absorbing material (eccosorb) was mounted to avoid reflection of waves
ばく露装置の詳細 the signal from a GSM test phone (Ericsson GH 337) was fed to an indoor base station antenna; two identical antennas were used, one mounted on each side of the participant's head at a distance of 4 cm from the ear, but only the right antenna was used; subjects were seated in a reclining chair in front of a LCD computer screen to watch a DVD during the session
Sham exposure A sham exposure was conducted.
Additional information trials were carried out in a room with low-frequency electric, magnetic and radiofrequency background fields low enough to be considered negligible
パラメータ
測定量 種別 Method Mass 備考
SAR 2 W/kg average over mass - 10 g -

ばく露2

主たる特性
周波数 890 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 1 hour
Modulation
Modulation type pulsed
Pulse width 0.577 ms
Repetition frequency 217 Hz
Additional information

signal from GSM test phone; no DTX was used

ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
Distance between exposed object and exposure source 4 cm
パラメータ
測定量 種別 Method Mass 備考
SAR 0.2 W/kg average over mass - 10 g -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露前
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

Statistically significant changes in transthyretin and beta-trace protein levels were found over the course of time in each exposure condition (SAR of 2 W/kg, 0.2 W/kg and sham exposure). However, no significant differences were found between exposure conditions with and without regard to the time of blood sampling.
The authors conclude that exposure to a 890 MHz electromagnetic field (GSM) did not show any effects on the human blood brain barrier permeability.

研究の種別:

研究助成

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