研究のタイプ: 医学/生物学の研究 (experimental study, review/survey)

[GSM-900携帯電話放射にばく露してから7日後の哺乳類の脳における血液脳関門の透過性上昇] med./bio.

Increased blood-brain barrier permeability in mammalian brain 7 days after exposure to the radiation from a GSM-900 mobile phone.

掲載誌: Pathophysiology 2009; 16 (2-3): 103-112

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研究目的(著者による)

To study the effects of GSM mobile phone irradiation upon the blood-brain barrier permeability of rats seven days after one occasion of 2 h of exposure and whether the same increase of the blood-brain barrier permeability is seen seven days after exposure as that showed immediately after exposure (see Persson et al. 1997) and after 14 days (see Eberhardt et al. 2008), and whether different exposure levels (SAR values) result in a different responses.
The first section of the article inculdes also a review of the literature on the effects (or lack of effects) of microwave exposure upon the blood-brain barrier.

詳細情報

48 rats were exposed at non-thermal specific absorption rates of 0 mW/kg (n=16), 0.12 mW/kg (n=8), 1.2 mW/kg (n=8), 12 mW/kg (n=8) and 120 mW/kg (n=8).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 915 MHz
Modulation type: pulsed
ばく露時間: continuous for 2 hr
  • 電力: 1 mW peak
  • 電力: 10 mW peak
  • 電力: 100 mW peak
  • 電力: 1,000 mW peak
  • SAR: 0.12 mW/kg average over mass (whole body)
  • SAR: 1.2 mW/kg average over mass (whole body)
  • SAR: 12 mW/kg average over mass (whole body)
  • SAR: 120 mW/kg average over mass (whole body)

ばく露1

主たる特性
周波数 915 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 2 hr
Modulation
Modulation type pulsed
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 GSM mobile phone connected via a coaxial cable to the TEM cell; TEM cell cenclosed in a 15 cm x 15 cm x 15 cm wooden box that supports the outer brass net conductor and the central conducting plate; rats placed in 14 cm x 14 cm x 7 cm plastic tray in the TEM cell
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電力 1 mW peak - - -
電力 10 mW peak - - -
電力 100 mW peak - - -
電力 1,000 mW peak - - -
SAR 0.12 mW/kg average over mass - whole body -
SAR 1.2 mW/kg average over mass - whole body -
SAR 12 mW/kg average over mass - whole body -
SAR 120 mW/kg average over mass - whole body -

Reference articles

  • Eberhardt JL et al. (2008): [GSM携帯電話からのマイクロ波ばく露の14日または28日後のラットにおける血液脳関門透過性と神経細胞損傷]
  • Salford LG et al. (2008): [人工的電磁界中に置かれた哺乳類の脳と血液脳関門機能、神経損傷、可能性のある物理的メカニズムの関連]
  • Nittby H et al. (2008): [GSM900携帯電話放射に長期ばく露されたラットの認知障害]
  • Salford LG et al. (2007): [哺乳類の脳におけるEMFの非熱効果:ルンドでの経験]
  • Belyaev IY et al. (2006): [915 MHzGSMマイクロ波へのラット脳のばく露は、遺伝子発現変化を誘導するが、二重鎖EDNAブレークまたはクロマチン形成への効果はない].
  • Persson BRR et al. (1997): [無線通信に用いられる電磁界にばく露されたラットでの血液脳関門透過性]
  • Salford LG et al. (1994): [915 MHz連続波電磁放射と変調(8,16, 50と200 Hz)電磁放射で誘発された血液脳関門の浸透性]
  • Salford LG et al. (1993): [915 MHz連続波電磁放射と変調(8,16, 50と200 Hz)電磁放射で誘発された血液脳関門の浸透性]

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

Albumin extravasation was statistically significant increased in the mobile phone exposed rats as compared to sham exposed controls after this 7-day recovery period at the SAR value of 12 mW/kg and with a trend of enhanced albumin extravasation also at the SAR values of 0.12 mW/kg and 120 mW/kg. There was a low, but significant correlation between the exposure level (SAR-value) and occurrence of focal albumin extravasation.
The data are in agreement with earlier studies of the authors (see above and "related articles") where they have seen increased permeability of blood-brain barrier immediately and 14 days after exposure.

研究の種別:

研究助成

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