研究のタイプ: 医学／生物学の研究 (experimental study)

[マウス海馬に対する2G携帯電話からの900-1800MHz電磁放射長期ばく露の影響：組織形態学的研究] med./bio.

Effects of Long Term Exposure of 900-1800 MHz Radiation Emitted from 2G Mobile Phone on Mice Hippocampus- A Histomorphometric Study

著者: Mugunthan N, Shanmugasamy K, Anbalagan J, Rajanarayanan S, Meenachi S
掲載誌: J Clin of Diagn Res 2016; 10 (8): AF01-AF06
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この研究は、2G携帯電話をばく露装置として、1日48分間の900-1800MHz電磁放射ばく露を30-180日間継続したマウスばく露群（n=36）と無ばく露対照群（匹数不明）について、海馬標本の組織形態学的変化を調べた。脳の摘出はばく露開始の1ヵ月後から6ヵ月後まで行った（間隔と回数は不明）。その結果、海馬のCA、CA2、DGDB領域のニューロン密度平均値は、ばく露開始の1ヵ月後から6ヵ月後まで､ばく露群の方が有意に低かった；一方CA3、DGVB領域では有意にニューロン密度が高かった､などの所見を報告している。

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研究目的（著者による）

The effects of chronic exposure of mice to a 900-1800 MHz electromagnetic field (2G) on hippocampus histology should be investigated.

詳細情報

Neonatal mice were divided into the following groups (n=6 each): exposure to the electromagnetic field for 1) 30 days, 2) 60 days, 3) 90 days, 4) 120 days, 5) 150 days and 6) 180 days. For each exposure group, a separate sham exposure group (n=6 mice, each) was used. Mice were killed 24 hours after exposure and subsequently investigated.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900–1,800 MHz
ばく露時間: intermittent for 2 minutes every 30 minutes over 12 hours per day (total of 48 minutes per day) for 30 days
  • SAR: 1.69 W/kg maximum (10 g)
ばく露2: 900–1,800 MHz
ばく露時間: intermittent for 2 minutes every 30 minutes over 12 hours per day (total of 48 minutes per day) for 60 days
  • SAR: 1.69 W/kg maximum (10 g)
ばく露3: 900–1,800 MHz
ばく露時間: intermittent for 2 minutes every 30 minutes over 12 hours per day (total of 48 minutes per day) for 90 days
  • SAR: 1.69 W/kg maximum (10 g)
ばく露4: 900–1,800 MHz
ばく露時間: intermittent for 2 minutes every 30 minutes over 12 hours per day (total of 48 minutes per day) for 120 days
  • SAR: 1.69 W/kg maximum (10 g)
ばく露5: 900–1,800 MHz
ばく露時間: intermittent for 2 minutes every 30 minutes over 12 hours per day (total of 48 minutes per day) for 150 days
  • SAR: 1.69 W/kg maximum (10 g)
ばく露6: 900–1,800 MHz
ばく露時間: intermittent for 2 minutes every 30 minutes over 12 hours per day (total of 48 minutes per day) for 180 days
  • SAR: 1.69 W/kg maximum (10 g)

ばく露1

主たる特性
周波数 900–1,800 MHz
タイプ
  • electromagnetic field
ばく露時間 intermittent for 2 minutes every 30 minutes over 12 hours per day (total of 48 minutes per day) for 30 days
ばく露装置
ばく露の発生源／構造
  • セルラ－電話
  • 2G mobile phone
チャンバの詳細 cages in the central animal house at 22 ± 1°C
ばく露装置の詳細 mobile phone was attached to the cage roof at a distance of 5 cm to the floor; animals could move freely; mobile phone was kept in non-vibrating, silent, Do Not Disturb mode with auto answer activated and was rung upon from another 2G phone for exposure
Sham exposure A sham exposure was conducted.
Additional information (remark EMF-Portal: the number of animals per cage is not stated)
パラメータ
測定量 値 種別 Method Mass 備考
SAR 1.69 W/kg maximum 測定値 10 g -
Additional parameter details

(remark EMF-Portal: The authors also state that "a 2G mobile phone operates ... with the power of 1.6 W/Kg" (?))

ばく露2

主たる特性
周波数 900–1,800 MHz
タイプ
  • electromagnetic field
ばく露時間 intermittent for 2 minutes every 30 minutes over 12 hours per day (total of 48 minutes per day) for 60 days
ばく露装置
ばく露の発生源／構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 1.69 W/kg maximum 測定値 10 g -

ばく露3

主たる特性
周波数 900–1,800 MHz
タイプ
  • electromagnetic field
ばく露時間 intermittent for 2 minutes every 30 minutes over 12 hours per day (total of 48 minutes per day) for 90 days
ばく露装置
ばく露の発生源／構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 1.69 W/kg maximum 測定値 10 g -

ばく露4

主たる特性
周波数 900–1,800 MHz
タイプ
  • electromagnetic field
ばく露時間 intermittent for 2 minutes every 30 minutes over 12 hours per day (total of 48 minutes per day) for 120 days
ばく露装置
ばく露の発生源／構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 1.69 W/kg maximum 測定値 10 g -

ばく露5

主たる特性
周波数 900–1,800 MHz
タイプ
  • electromagnetic field
ばく露時間 intermittent for 2 minutes every 30 minutes over 12 hours per day (total of 48 minutes per day) for 150 days
ばく露装置
ばく露の発生源／構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 1.69 W/kg maximum 測定値 10 g -

ばく露6

主たる特性
周波数 900–1,800 MHz
タイプ
  • electromagnetic field
ばく露時間 intermittent for 2 minutes every 30 minutes over 12 hours per day (total of 48 minutes per day) for 180 days
ばく露装置
ばく露の発生源／構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 1.69 W/kg maximum 測定値 10 g -

Reference articles

  • Mugunthan N et al. (2015): [2Gおよび3G携帯電話放射への慢性ばく露のマウスの精巣への影響：無作為化対照比較試験]
  • Mugunthan N et al. (2014): [マウス精巣に対する2G携帯電話放射 (900 - 1900 MHz) への長期ばく露の影響]

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

The mean density of neurons was significantly decreased in hippocampus regions CA1, CA2 and DGDB and significantly increased in CA3 and DGVB regions from animals of all exposure groups compared to respective sham exposed animals. The CA3 region in group 2 was the only exception with no significant differences found.
The mean nuclear diameter of neurons was significantly decreased in all hippocampus regions from animals of all exposure groups compared to respective sham exposed animals. The CA3 region in group 2, the DGDB region in group 4 and the DGVB region in group 3 were the only exceptions with no significant differences found.
The authors conclude that chronic exposure of mice to a 900-1800 MHz electromagnetic field (2G) might reduce the density and nuclear diameter of neurons in the hippocampus.

研究の種別:

研究助成

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