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ばく露時間: continuous for 5 days
|ばく露時間||continuous for 5 days|
|ばく露装置の詳細||Helmholtz coil pair placed inside a cell culture incubator; power supply signal was attenuated by a variac and fed to the coils to produce magnetic field|
|Sham exposure||A sham exposure was conducted.|
|磁束密度||1 mT||effective value||測定値||-||-|
Both immunohistochemical staining and Western blot showed a significant increase in neuronal differentiation of cells in the exposure group compared to the sham exposure group. The differentiated neurons in the exposure group also showed significantly longer axons and a significantly increased level of c-Fos compared to the sham exposure group. Addition of the NMDA receptor inhibitor memantine reversed these effects.
The authors conclude that exposure of human stem cells to a 50 Hz magnetic field could promote neuronal differentiation with the involvement of the NMDA receptor.