研究のタイプ: 医学/生物学の研究 (experimental study)

Extremely low frequency magnetic field induces human neuronal differentiation through NMDA receptor activation. med./bio.

掲載誌: J Neural Transm (Vienna) 2019 [in press]

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研究目的(著者による)

The effects of exposure of human stem cells to a 50 Hz magnetic field on neuronal differentiation and the involvement of the NMDA receptor should be investigated.

詳細情報

Cells were divided into an exposure group and a sham exposure group. To investigate the role of the NMDA receptor, the cells were partially treated with memantine, an NMDA receptor antagonist.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50 Hz
ばく露時間: continuous for 5 days

ばく露1

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
波形
  • sinusoidal
ばく露時間 continuous for 5 days
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 Helmholtz coil pair placed inside a cell culture incubator; power supply signal was attenuated by a variac and fed to the coils to produce magnetic field
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
磁束密度 1 mT effective value 測定値 - -

Reference articles

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

Both immunohistochemical staining and Western blot showed a significant increase in neuronal differentiation of cells in the exposure group compared to the sham exposure group. The differentiated neurons in the exposure group also showed significantly longer axons and a significantly increased level of c-Fos compared to the sham exposure group. Addition of the NMDA receptor inhibitor memantine reversed these effects.
The authors conclude that exposure of human stem cells to a 50 Hz magnetic field could promote neuronal differentiation with the involvement of the NMDA receptor.

研究の種別:

研究助成

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