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To investigate the possible protective role of melatonin on oxidative stress generated by exposure to a WiFi-signal in rats.
Four groups (n=8 per group) were examined: 1.) cage control, 2.) sham exposure + saline injection. 3.) exposure and 4.) exposure + melatonin injection.
|ばく露時間||continuous for 60 min/d for 30 days (28 days? different indications in the article)|
|Repetition frequency||217 Hz|
|Distance between exposed object and exposure source||1 m|
|チャンバの詳細||exposure system was organized with a special cylindrical strainer which is appropriate for exposure condition and physical size of one rat (length 15 cm, diameter 5 cm), noses of rats were positioned in close contact to the antenna (according to a table in the article: distance between head and antenna 1 m (?)) and the tube was ventilated from head to tail to decrease stress, 8 rats (Figure shows 6 rats (?)) exposed at the same time|
|ばく露装置の詳細||whole exposure system was kept in a Faraday cage|
|Sham exposure||A sham exposure was conducted.|
In the exposed group, the amount of lipid peroxidation was significantly increased compared to the cage control and the sham exposed group, while an administration of melatonin prevented this effect. No differences in the level of reduced glutathione were found between the groups. The enzyme activity of the glutathione peroxidase was lower (not significantly) in the exposed group than in the cage control and the sham exposure group. However, in the exposure group with melatonin administration, the enzyme activity of the glutathione peroxidase was significantly increased compared to the exposure group without melatonin administration.