研究のタイプ: 医学/生物学の研究 (experimental study)

[ラット喉頭気管粘膜における無線(2.45GHz)誘発性酸化毒性のメラトニンによる修飾] med./bio.

Modulation of wireless (2.45 GHz)-induced oxidative toxicity in laryngotracheal mucosa of rat by melatonin.

掲載誌: Eur Arch Otorhinolaryngol 2013; 270 (5): 1695-1700

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研究目的(著者による)

To investigate the possible protective role of melatonin on oxidative stress generated by exposure to a WiFi-signal in rats.

詳細情報

Four groups (n=8 per group) were examined: 1.) cage control, 2.) sham exposure + saline injection. 3.) exposure and 4.) exposure + melatonin injection.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2,450 MHz
Modulation type: pulsed
ばく露時間: continuous for 60 min/d for 30 days (28 days? different indications in the article)
  • 電界強度: 11.07 V/m effective value (closest point to body)
  • SAR: 0.143 W/kg effective value (whole body)
  • SAR: 4.2 W/kg maximum

ばく露1

主たる特性
周波数 2,450 MHz
タイプ
  • electromagnetic field
波形
  • pulsed
ばく露時間 continuous for 60 min/d for 30 days (28 days? different indications in the article)
Modulation
Modulation type pulsed
Repetition frequency 217 Hz
ばく露装置
ばく露の発生源/構造
  • half-wave dipole or monopole (varying indications within the text; remark EMF-Portal)
Distance between exposed object and exposure source 1 m
チャンバの詳細 exposure system was organized with a special cylindrical strainer which is appropriate for exposure condition and physical size of one rat (length 15 cm, diameter 5 cm), noses of rats were positioned in close contact to the antenna (according to a table in the article: distance between head and antenna 1 m (?)) and the tube was ventilated from head to tail to decrease stress, 8 rats (Figure shows 6 rats (?)) exposed at the same time
ばく露装置の詳細 whole exposure system was kept in a Faraday cage
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電界強度 11.07 V/m effective value 測定値 - closest point to body
SAR 0.143 W/kg effective value 計算値 whole body -
SAR 4.2 W/kg maximum 計算値 - -

Reference articles

  • Gumral N et al. (2009): [無線装置からの2.45GHz放射によるラット血液中の酸化ストレスに対するセレンおよびL-カルニチンの効果]

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

In the exposed group, the amount of lipid peroxidation was significantly increased compared to the cage control and the sham exposed group, while an administration of melatonin prevented this effect. No differences in the level of reduced glutathione were found between the groups. The enzyme activity of the glutathione peroxidase was lower (not significantly) in the exposed group than in the cage control and the sham exposure group. However, in the exposure group with melatonin administration, the enzyme activity of the glutathione peroxidase was significantly increased compared to the exposure group without melatonin administration.

研究の種別:

研究助成

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