研究のタイプ: 医学/生物学の研究 (experimental study)

[マイクロ波ばく露による雄ラットの生殖系への影響] med./bio.

Microwave exposure affecting reproductive system in male rats.

掲載誌: Appl Biochem Biotechnol 2010; 162 (2): 416-428

この実験研究は、50 GHz電磁界がWistar系の雄ラット生殖系に及ぼす影響を調べた。生後60日の動物を2群(ばく露群、擬似ばく露群)に分け、換気穴付きプレキシガラス製容器内に拘束して、継続的に一日2時間ずつ45日間、一定のSAR 8.0×10-4W/kgでのばく露、または擬似ばく露を行った。ばく露後屠殺して採取した精液において、擬似ばく露群に比較してばく露群では、スーパーオキシドディスムターゼ(SOD)、グルタチオンペルオキシダーゼ(GPx)の有意な低下(p≦0.05)、カタラーゼ有意な増加(p < 0.02)、ヒストンキナーゼ平均活性の有意な低下(p < 0.016)、アポトーシスの増加(p < 0.004)などが観察されたと報告している。

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研究目的(著者による)

To study the effects of 50 GHz microwave electromagnetic fields on the reproductive system of male rats.

詳細情報

12 rats were divided into one exposure group (6 animals) and one sham exposure group.
The investigated parameters "histone kinase" and "cell cycle" are correlated to each other.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50 GHz
Modulation type: CW
ばく露時間: continuous for 2 h/day on 45 days

ばく露1

主たる特性
周波数 50 GHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 2 h/day on 45 days
Modulation
Modulation type CW
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 two rats in a 31 cm x 9.2 cm x 8.5 cm Plexiglas cage, cage placed in an exposure chamber lined with radar absorbing material, horn antenna place beside the long side of the cage
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電力密度 0.86 µW/cm² - 測定値 - -
SAR 0.8 mW/kg - 計算値 whole body -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

The data showed that prolonged exposure to the 50 GHz electromagnetic field may decrease the enzyme activities of histone kinase, glutathione peroxidase and superoxide dismutase. On the other hand, the enzyme activity of catalase and the amount of cells in apoptosis phase were increased in the exposed group. Moreover, it was confirmed that a decrease in cells in G2 phase-M phase (mitosis phase) is directly related to histone kinase enzyme activity. The authors suggest that a reduction or an increase in enzyme activities of antioxidants and histone kinase, and the levels in cell cycle observed under these experimental conditions may be related to an overproduction of reactive oxygen species under microwave exposure.
The authors conclude that these irradiations may have a significant effect on the reproductive system of male rats, which may be an indication of male infertility.

研究の種別:

研究助成

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