研究のタイプ: 医学/生物学の研究 (experimental study)

[携帯電話放射はin vitroでヒト精子細胞に活性酸素種産生及びDNA損傷を誘導する] med./bio.

Mobile phone radiation induces reactive oxygen species production and DNA damage in human spermatozoa in vitro.

掲載誌: PLoS One 2009; 4 (7): e6446

ヒトの男性の生殖機能に対する携帯電話放射の影響については議論されているが、関与するメカニズムが確立されていない。ヒトの精子は特に酸化ストレスの影響を受け易いことを考慮して、1.8 GHzで、SARが0.4 W/kg から27.5 W/kgの無線周波電磁界ばく露の影響を調べた。 その結果、SARの上昇と共に、精子の運動率と生存率が低下し、ミトコンドリアでの活性酸素種産生とDNA断片化が上昇したことを報告している。

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研究目的(著者による)

To study the influence of radiofrequency electromagnetic fields on the cell biology (e.g. oxidative stress, DNA damage) of human spermatozoa in vitro (of 22 healthy donors).

詳細情報

In order to control thermal effects of radiofrequency electromagnetic field exposure, spermatozoa were also incubated at temperatures ranging from 21°C - 50°C for 2 h.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 1.8 GHz
ばく露時間: continuous for 16 hr
  • SAR: 0.4 W/kg minimum
  • SAR: 27.5 W/kg maximum

ばく露1

主たる特性
周波数 1.8 GHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 16 hr
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 cylindrical waveguide whose the end was filled with 15 cm thick carbon-impregnated foam placed inside a brass mesh Faraday cage; petri dishes positioned inside the waveguide
パラメータ
測定量 種別 Method Mass 備考
SAR 0.4 W/kg minimum 校正 - -
SAR 27.5 W/kg maximum 校正 - -

Reference articles

  • Gajda GB et al. (2002): [1.9 GHzのラジオ周波数電磁界に細胞をIn vitroばく露するための円筒状導波管アプリケータ]

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露前
  • ばく露後

研究の主なアウトカム(著者による)

Sperm motility and sperm vitality were significantly reduced after radiofrequency electromagnetic field exposure with increasing SAR values, while the mitochondrial generation of reactive oxygen species and DNA fragmentation were significantly elevated. Furthermore, highly significant relationships between SAR, the oxidative DNA damage marker, 8-OH-dG, and DNA fragmentation after exposure were also observed.
In conclusion, radiofrequency electromagnetic field exposure in both the power density and frequency range of mobile phones enhances mitochondrial reactive oxygen species generation in human spermatozoa, decreasing the sperm motility and sperm vitality while stimulating DNA fragmentation. These data have clear implications for the safety of extensive mobile phone use by males of reproductive age, potentially affecting both their fertility and the health and well-being of their offspring.

研究の種別:

研究助成

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