ヒトの男性の生殖機能に対する携帯電話放射の影響については議論されているが、関与するメカニズムが確立されていない。ヒトの精子は特に酸化ストレスの影響を受け易いことを考慮して、1.8 GHzで、SARが0.4 W/kg から27.5 W/kgの無線周波電磁界ばく露の影響を調べた。 その結果、SARの上昇と共に、精子の運動率と生存率が低下し、ミトコンドリアでの活性酸素種産生とDNA断片化が上昇したことを報告している。
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To study the influence of radiofrequency electromagnetic fields on the cell biology (e.g. oxidative stress, DNA damage) of human spermatozoa in vitro (of 22 healthy donors).
In order to control thermal effects of radiofrequency electromagnetic field exposure, spermatozoa were also incubated at temperatures ranging from 21°C - 50°C for 2 h.
|ばく露時間||continuous for 16 hr|
|ばく露装置の詳細||cylindrical waveguide whose the end was filled with 15 cm thick carbon-impregnated foam placed inside a brass mesh Faraday cage; petri dishes positioned inside the waveguide|
Sperm motility and sperm vitality were significantly reduced after radiofrequency electromagnetic field exposure with increasing SAR values, while the mitochondrial generation of reactive oxygen species and DNA fragmentation were significantly elevated. Furthermore, highly significant relationships between SAR, the oxidative DNA damage marker, 8-OH-dG, and DNA fragmentation after exposure were also observed.
In conclusion, radiofrequency electromagnetic field exposure in both the power density and frequency range of mobile phones enhances mitochondrial reactive oxygen species generation in human spermatozoa, decreasing the sperm motility and sperm vitality while stimulating DNA fragmentation. These data have clear implications for the safety of extensive mobile phone use by males of reproductive age, potentially affecting both their fertility and the health and well-being of their offspring.