研究のタイプ: 医学/生物学の研究 (experimental study)

[ラットにおける1.8 GHz無線周波電磁界誘導の酸化ストレスとニンニク抽出物の作用] med./bio.

Oxidative stress induced by 1.8 GHz radio frequency electromagnetic radiation and effects of garlic extract in rats.

掲載誌: Int J Radiat Biol 2012; 88 (11): 799-805

この研究は、1.8GHz無線周波電磁界RF-EMF)が誘導する酸化ストレスとその損傷を防護するニンニク抽出物の抗酸化作用をラットで調べた。アルビノWistarラット66匹を22匹ずつ、RF-EMF群(SAR 0.4 W/kg、1日1時間、3週間ばく露)、RF-EMF+ニンニク群(同じRF-EMFばく露、かつ500 mg/体重1kgのニンニク抽出液の経胃内栄養チューブ投与)、対照群に分け、ばく露後の血液・脳組織を調べた。その結果、対照群に比べ、RF-EMF群では脳組織タンパク質過酸化物(AOPP)レベルが有意に上昇した;一方、RF-EMF+ニンニク群ではAOPPレベルは有意に低下した;血漿NOレベルに関しては、RF-EMF群、RF-EMF+ニンニク群で共に有意に上昇し、両者のレベルに有意差はなかった、などの所見を報告している。

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研究目的(著者による)

To study the oxidative damage induced by radiofrequency electromagnetic exposure emitted by mobile telephones and the protective effect of a garlic extract used as an antioxidant.

詳細情報

66 rats were divided into three groups (n=22 per group): 1.) exposure group, 2.) exposure + garlic administration (500 mg/kg/d) and 3.) control group. At the end of the study, blood and brain tissues were collected.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 1,750–1,850 MHz
ばく露時間: continuous for 1 h/day during 3 weeks

General information

Rats were divided into the following three groups: i) EMF exposure ii) EMF exposure + daily treatment with 500 mg/kg body weight garlic extract iii) control

ばく露1

主たる特性
周波数 1,750–1,850 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 1 h/day during 3 weeks
Modulation
Modulation type cf. additional information
Additional information

GSM

ばく露装置
ばく露の発生源/構造
  • モノポール
  • GSM simulator
Distance between exposed object and exposure source 6 cm
ばく露装置の詳細 rats kept during exposure in plastic constrainers positioned radially around a 15 cm high antenna
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電力 1 W - - - output power
SAR 0.4 W/kg - 計算値 whole body -
電界強度 17.23 V/m average over time 測定値 - ± 1.48 V/m

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

No differences among the groups with regard to the malondialdehyde levels in serum and brain tissue were detected. Although the serum "advanced oxidation protein products" levels did not differ among the groups, the "advanced oxidation protein products" levels in the brain homogenates of the exposed group were higher than those of the control group. In the exposed group with garlic administration, there was a statistically significant decrease in the "advanced oxidation protein products" levels compared to the exposed group. There was no statistically significant difference between the control group and the exposed group with garlic administration. The serum nitric oxide levels increased significantly in the exposed group and in the exposed group with garlic administration compared with the control group. However, there was no difference between the exposed group and the exposed group with garlic administration regarding the serum nitric oxide levels. No differences were found in the serum levels of paraoxonase among the groups. No paraoxonase was found in the brain homogenates.
The authors summarize that the exposure to a radiofrequency electromagnetic field at 1.8 GHz did not cause lipid peroxidation and nitric oxide increase but led to protein oxidation in the brain tissue and an increase in serum nitric oxide level. Furthermore, an administration of garlic reduced the protein oxidation in the brain tissue but did not have any effects on serum nitric oxide levels.

研究の種別:

研究助成

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