研究のタイプ: 医学/生物学の研究 (experimental study)

Electromagnetic field of extremely low frequency (60Hz and 120Hz) effects the cell cycle progression and the metabolic activity of the anterior pituitary gland cells in vitro. med./bio.

掲載誌: 著者のリストなし, IEEE EUROCON 2017 -17th International Conference on Smart Technologies, Ohrid. IEEE, 2017: 537-541, ISBN 9781509038442

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研究目的(著者による)

The effects of exposure of pig anterior pituitary cells to a 60 Hz or 120 Hz magnetic field on cell cycle progression and cell viability should be investigated.

詳細情報

The cells were divided into the following groups: 1) exposure to a 60 Hz magnetic field with 2 - 6 mT, 2) 1) exposure to a 120 Hz magnetic field with 2 - 6 mT, 3) exposure to a 60 Hz magnetic field with 2 - 6 mT and subsequent further incubation without exposure for 24 hours, 4) exposure to a 120 Hz magnetic field with 2 - 6 mT and subsequent further incubation without exposure for 24 hours. A separate control group was used for each exposure condition.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 60 Hz
ばく露時間: 2 hours
ばく露2: 120 Hz
ばく露時間: 2 hours

ばく露1

主たる特性
周波数 60 Hz
タイプ
  • magnetic field
ばく露時間 2 hours
ばく露装置
ばく露の発生源/構造
  • generator (Magneris)
チャンバの詳細 cells were seeded in 96-well plates
パラメータ
測定量 種別 Method Mass 備考
磁束密度 2 mT - - - -
磁束密度 2.5 mT - - - -
磁束密度 3 mT - - - -
磁束密度 4 mT - - - -
磁束密度 6 mT - - - -

ばく露2

主たる特性
周波数 120 Hz
タイプ
  • magnetic field
ばく露時間 2 hours
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
パラメータ
測定量 種別 Method Mass 備考
磁束密度 2 mT - - - -
磁束密度 2.5 mT - - - -
磁束密度 3 mT - - - -
磁束密度 4 mT - - - -
磁束密度 6 mT - - - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

In all groups, the proportion of cells in the G0/G1 phase was significantly increased compared to the respective control group, while the proportion of cells in the S phase was significantly reduced. The effects of the 60 Hz magnetic fields (groups 1 and 3) were significantly stronger compared to the 120 Hz groups (groups 2 and 4). (Note EMF-Portal: No information was provided on the magnetic flux density used in cell cycle progression experiments.) These results indicated an anti-proliferative effect of magnetic field exposure.
Cell viability was significantly increased in all groups and at all magnetic flux densities compared to the control groups.
The authors conclude that exposure of pig anterior pituitary cells to a 60 Hz or 120 Hz magnetic field could have an anti-proliferative effect by influencing cell cycle progression.

研究の種別:

研究助成

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