研究のタイプ: 医学/生物学の研究 (experimental study)

[携帯電話の長期使用における網膜の酸化ストレスに対するメラトニンおよびカフェイン酸フェネチルエステルの保護効果:比較研究] med./bio.

Protective effects of melatonin and caffeic acid phenethyl ester against retinal oxidative stress in long-term use of mobile phone: a comparative study.

掲載誌: Mol Cell Biochem 2006; 282 (1-2): 83-88

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研究目的(著者による)

To compare the protective effects of melatonin and CAPE against 900 MHz electromagnetic field-induced retinal oxidative stress.

詳細情報

Caffeic acid phenethyl ester (CAPE) is one of the major components of honeybee propolis. It has been used in folk medicine for many years in Middle East countries. Melatonin and CAPE were found to be potent free radical scavengers and antioxidants.
Melatonin (100 µg/kg) or CAPE (10 µM/ml per kg per day) were administered daily for 60 days to the animals prior to their electromagnetic field exposure.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: pulsed
ばく露時間: repeated daily exposure for 30 min/day for 60 days
  • 電力: 2 W peak
  • 電力密度: 1.04 mW/cm²
  • SAR: 0.016 W/kg average over mass (whole body)
  • SAR: 4 W/kg average over mass (brain)

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
ばく露時間 repeated daily exposure for 30 min/day for 60 days
Modulation
Modulation type pulsed
Repetition frequency 217 Hz
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 A special exposure device with six-exposure antennas for insulated exposure was used. The exposure system for an animal consisted of a plastic tube cage (length 12 cm, diameter 5 cm) and a half wave dipole antenna. The head of the rat was positioned in close contact above the dipole antenna. The tube was ventilated from head to tail.
パラメータ
測定量 種別 Method Mass 備考
電力 2 W peak - - -
電力密度 1.04 mW/cm² - 測定値 - -
SAR 0.016 W/kg average over mass 測定値 whole body -
SAR 4 W/kg average over mass 測定値 brain -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
  • 感覚器
  • eye (retina)
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

Retinal levels of nitric oxide and malondialdehyde increased in the electromagnetic field exposed rats while both melatonin and CAPE caused a significant reduction in the levels of nitric oxide and malondialdehyde.
Likewise, retinal superoxide dismutase, glutathione peroxidase and catalase activities decreased in electromagnetic field exposed animals while melatonin and CAPE caused a significant increase in the activities of these antioxidant enzymes in the exposed animals to higher levels than those of control rats.
In conclusion, melatonin and CAPE reduce retinal oxidative stress after long-term exposure to 900 MHz emitting mobile phone. Nevertheless, there was no statistically significant difference between the efficacies of these two antioxidants against to electromagnetic field induced oxidative stress. The difference was in only glutathione peroxidase activity. Melatonin stimulated the retinal glutathione peroxidase activity more efficiently than CAPE did.

研究の種別:

研究助成

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