研究のタイプ: 医学/生物学の研究 (experimental study)

[ラットにおける携帯電話誘発腎障害に対するメラトニンおよびカフェイン酸フェネチルエステル(CAPE)の保護効果の比較分析] med./bio.

Comparative analysis of the protective effects of melatonin and caffeic acid phenethyl ester (CAPE) on mobile phone-induced renal impairment in rat.

掲載誌: Mol Cell Biochem 2005; 276 (1-2): 31-37

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研究目的(著者による)

To compare the protective effects of melatonin and CAPE against 900 MHz electromagnetic field-induced renal tubular injury.

詳細情報

Caffeic acid phenethyl ester (CAPE) is one of the major components of honeybee propolis. It has been used in folk medicine for many years in Middle East countries. Melatonin and CAPE were found to be potent free radical scavengers and antioxidants.
ROS such as superoxide and nitric oxide may contribute to the pathophysiology of electromagnetic irradiation-induced renal impairment.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: CW
ばく露時間: repeated daily exposure, 30 min/day for 10 days

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
ばく露時間 repeated daily exposure, 30 min/day for 10 days
Modulation
Modulation type CW
ばく露装置
ばく露の発生源/構造
チャンバの詳細 The exposure system consisted of a ventilated plastic tube cage (12 cm long x 5.5 cm in diameter) and a dipole antenna.
ばく露装置の詳細 The whole body of the rat was positioned in close contact above the antenna.
Additional information Rats were allocated to four groups: sham exposed, EMR exposed, EMR exposed + melatonin treated, and EMR exposed + CAPE treated. Melatonin dissolved in ethanol/saline was injected s.c., and CAPE was injected i.p. daily immediately before exposure. Sham exposed rats were injected with isotonic saline solution instead.
パラメータ
測定量 種別 Method Mass 備考
電力 2 W peak - - -
電力密度 1.04 mW/cm² mean 測定値 - -
SAR 1.04 W/kg mean 測定値 - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
  • kidney
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

Urinary NAG and renal malondialdehyde were increased in electromagnetic field exposed animals while both melatonin and CAPE caused a significant reduction in the levels of these parameters but the effect of melatonin was more potent than that of CAPE. Likewise, renal superoxide dismutase and glutathione peroxidase activities were decreased in exposed rats while melatonin caused a significant increase in the activities of these antioxidant enzymes but CAPE did not.
In conclusion, melatonin and CAPE prevent renal tubular injury by reducing oxidative stress and protect the kidney from oxidative damage induced by mobile phone (900 MHz). Nevertheless, melatonin seems to be a more potent antioxidant in comparison to CAPE in kidney.

研究の種別:

研究助成

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