研究のタイプ: 医学/生物学の研究 (experimental study)

[カフェイン酸フェネチルエステルは、ラット肝臓において1800 MHzのマイクロ波誘起酸化ストレスを調節する] med./bio.

Caffeic Acid Phenethyl Ester Modulates 1800 MHz Microwave-Induced Oxidative Stress in Rat Liver.

掲載誌: Electromagn Biol Med 2005; 24 (2): 135-142

The detailed summary of this article is not available in your language or incomplete. Would you like to see a complete translation of the summary? Then please contact us →

研究目的(著者による)

To study the effects of microwaves on the liver oxidant/antioxidant system as well as the possible protective effects of CAPE on the liver toxicity induced by microwaves.

詳細情報

Caffeic acid phenethyl ester (CAPE) is one of the major components of honeybee propolis. CAPE is found to be a potent free radical scavenger and antioxidant.
CAPE was injected for 30 days before exposure to microwaves. 29 rats were divided into three groups: control, microwave exposure and "microwave exposure + CAPE administration".

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 1,800 MHz
Modulation type: pulsed
ばく露時間: repeated daily exposure, 1 h/day, for 30 days

ばく露1

主たる特性
周波数 1,800 MHz
タイプ
  • electromagnetic field
ばく露時間 repeated daily exposure, 1 h/day, for 30 days
Modulation
Modulation type pulsed
Repetition frequency 217 Hz
ばく露装置
ばく露の発生源/構造
チャンバの詳細 A special exposure device with five antennas was used.
ばく露装置の詳細 Rats were individually placed in ventilated round plastic tube cages (12 cm long x 5.5 cm in diameter) that were positioned in close contact above the antenna.
Sham exposure A sham exposure was conducted.
Additional information In control (sham) and RF-only exposed rats, an equal volume of isotonic saline solution was administered i.p. instead of CAPE.
パラメータ
測定量 種別 Method Mass 備考
電力密度 1 mW/cm² mean 測定値 - ± 0.04 mW/cm²
SAR 2 W/kg peak 指定なし - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
  • liver
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

The activities of xanthine oxidase, catalase and level of lipid peroxidation increased in microwave exposed animals compared with the control group although xanthine oxidase and lipid peroxidation levels were decreased by "microwave exposure + CAPE administration".
The activities of superoxide dismutase and glutathione peroxidase decreased in the microwave exposed group compared with the control group. Their levels were increased by "microwave expsoure + CAPE administration".
The authors conclude that CAPE may prevent microwave-induced oxidative changes in liver by strengthening the antioxidant defense system, by reducing reactive oxygen species, and by increasing antioxidant enzyme activities.

研究の種別:

研究助成

関連論文