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To study the effects of microwaves on the liver oxidant/antioxidant system as well as the possible protective effects of CAPE on the liver toxicity induced by microwaves.
Caffeic acid phenethyl ester (CAPE) is one of the major components of honeybee propolis. CAPE is found to be a potent free radical scavenger and antioxidant.
CAPE was injected for 30 days before exposure to microwaves. 29 rats were divided into three groups: control, microwave exposure and "microwave exposure + CAPE administration".
|ばく露時間||repeated daily exposure, 1 h/day, for 30 days|
|Repetition frequency||217 Hz|
|チャンバの詳細||A special exposure device with five antennas was used.|
|ばく露装置の詳細||Rats were individually placed in ventilated round plastic tube cages (12 cm long x 5.5 cm in diameter) that were positioned in close contact above the antenna.|
|Sham exposure||A sham exposure was conducted.|
|Additional information||In control (sham) and RF-only exposed rats, an equal volume of isotonic saline solution was administered i.p. instead of CAPE.|
The activities of xanthine oxidase, catalase and level of lipid peroxidation increased in microwave exposed animals compared with the control group although xanthine oxidase and lipid peroxidation levels were decreased by "microwave exposure + CAPE administration".
The activities of superoxide dismutase and glutathione peroxidase decreased in the microwave exposed group compared with the control group. Their levels were increased by "microwave expsoure + CAPE administration".
The authors conclude that CAPE may prevent microwave-induced oxidative changes in liver by strengthening the antioxidant defense system, by reducing reactive oxygen species, and by increasing antioxidant enzyme activities.