研究のタイプ: 医学/生物学の研究 (experimental study)

[コード分​​割多重アクセスまたは周波数DMAの無線周波放射への慢性ばく露後の発現変化遺伝子の数は偽陽性率を超えない] med./bio.

The number of genes changing expression after chronic exposure to Code Division Multiple Access or Frequency DMA radiofrequency radiation does not exceed the false-positive rate.

掲載誌: Proteomics 2006; 6 (17): 4739-4744

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研究目的(著者による)

To study if exposure to cell phone radiofrequency irradiations induce changes in gene expression.

詳細情報

The experiments were repeated three times each for both CDMA and FDMA exposures.
Cells exposed to 0.68 Gy of X-rays were used as positive controls.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 835.62 MHz
ばく露時間: continuous for 24 h
FDMA
  • SAR: 5 W/kg average over time (± 2.1 W/kg)
ばく露2: 847.74 MHz
Modulation type: pulsed
ばく露時間: continuous for 24 h
CDMA
  • SAR: 5 W/kg average over time (± 2.1 W/kg)

General information

A detailed description of the RTL device and its environmental controls has been given in several publications [Moros et al., 1998 and 1999; Pickard et al., 1999 and 2000].

ばく露1

主たる特性
周波数 835.62 MHz
タイプ
  • electromagnetic field
特性
  • guided field
ばく露時間 continuous for 24 h
Additional information FDMA
Modulation
Modulation type cf. additional information
Additional information

FDMA, dithered ± 0.015 MHz

ばく露装置
ばく露の発生源/構造
チャンバの詳細 The radial transmission line (RTL) was formed by two horizontal parallel electrically conducting plates. A central conical aluminium antenna emitted TEM waves radially outward that were terminated by an annulus of RF-absorbing foam. The thermally conductive aluminium bottom plate (6 mm thick) minimised temperature gradients among the exposed flasks placed equidistantly around the antenna. The temperature of the culture media during RF and sham exposure was 37 ± 0.3°C [Moros et al., 1999].
ばく露装置の詳細 Both powered and sham RTLs were loaded with 16 T75 culture flasks containing 40 ml of culture medium, 15 of them being dummy flasks.
Sham exposure A sham exposure was conducted.
Additional information For positive control, cultured cells were first maintained in the incubator for an additional 24 h (to mirror the length of RF exposure), then irradiated with 0.68 Gy of X-rays, and afterwards placed back into the incubator for a 4-h recovery. Another identically treated flask of cells was sham exposed in the X-ray irradiator.
パラメータ
測定量 種別 Method Mass 備考
SAR 5 W/kg average over time - - ± 2.1 W/kg

ばく露2

主たる特性
周波数 847.74 MHz
タイプ
  • electromagnetic field
特性
  • guided field
ばく露時間 continuous for 24 h
Additional information CDMA
Modulation
Modulation type pulsed
Pulse width 1.25 ms
Duty cycle 40 %
Additional information

CDMA, nominally spread 1.2288 MHz, dropping off rapidly beyond the band edge (-50.5 dBc at ± 900 kHz). Time domain behaviour consisting of 1.25-ms pulses with pseudorandom spacing and an approximate 40% duty cycle.

ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
SAR 5 W/kg average over time - - ± 2.1 W/kg

Reference articles

  • Pickard WF et al. (2000): [誘電体装荷放射状送電線における培養瓶内のSAR分布の実験的および数的測定]
  • Pickard WF et al. (1999): [横断電磁モードばく露装置内の培養フラスコ内での比吸収率分布の簡易モデルおよび計測]
  • Moros EG et al. (1999): [大量の培養瓶へのマイクロ波照射用広帯域遮蔽ばく露装置としての放射状送電線]
  • Moros EG et al. (1998): [小動物の長期間のUHF照射用のコンパクトなばく露装置:1電磁および環境面を考慮した設計]

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

The number of gene expression changes induced by irradiation was not greater than the number of false positives expected based on a sham exposure versus sham exposure comparison.
In contrast, the X-rays radiated samples showed higher number of gene expression changes than in the sham exposure versus sham exposure comparison.

研究の種別:

研究助成

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