研究のタイプ: 医学/生物学の研究 (experimental study)

[1.9 GHzパルス変調ラジオ周波数場へのin vitroでばく露されたヒト由来細胞の発ガン遺伝子と熱ショックタンパク遺伝子発現の解析] med./bio.

Analysis of proto-oncogene and heat-shock protein gene expression in human derived cell-lines exposed in vitro to an intermittent 1.9 GHz pulse-modulated radiofrequency field.

掲載誌: Int J Radiat Biol 2006; 82 (5): 347-354

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研究目的(著者による)

To study the effects of radiofrequency fields, emitted by mobile phones, on gene expression in cultured human cell lines at 0 and 18 h after exposure.

詳細情報

All samples were compared to sham-exposed, negative (incubator) and positive (heat shock, 1 h at 43°C) controls at 0 and 18 h after exposure.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 1.9 GHz
Modulation type: pulsed
ばく露時間: intermittent, 5 min on/10 min off, for 6 h
  • SAR: 1 W/kg mean (±24%)
  • SAR: 10 W/kg mean (±24%)

ばく露1

主たる特性
周波数 1.9 GHz
タイプ
  • electromagnetic field
偏波
  • circular
ばく露時間 intermittent, 5 min on/10 min off, for 6 h
Modulation
Modulation type pulsed
ばく露装置
ばく露の発生源/構造
チャンバの詳細 The temperature in the cell cultures was maintained at 37.0 ± 0.5°C.
ばく露装置の詳細 Cells were exposed in 10 ml of culture medium in 60-mm Petri dishes placed atop circularly polarized cylindrical waveguide applicators.
Sham exposure A sham exposure was conducted.
Additional information Negative and positive (heat shock) controls were run concurrently with each experiment.
パラメータ
測定量 種別 Method Mass 備考
SAR 1 W/kg mean 指定なし - ±24%
SAR 10 W/kg mean 指定なし - ±24%

Reference articles

  • Gajda GB et al. (2002): [1.9 GHzのラジオ周波数電磁界に細胞をIn vitroばく露するための円筒状導波管アプリケータ]

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

No significant effects were observed in mRNA expression of hsp27, hsp70, c-jun, c-myc or c-fos in comparison of the sham-exposed and radiofrequency-exposed groups, in either of the two cell lines. However, the positive control displayed a significant elevation in the expression of hsp27, hsp70, c-fos and c-jun in both cell lines compared to the sham-exposed and negative control groups.
The data revealed no evidence that exposure of cells to non-thermal levels of 1.9 GHz pulse modulated radiofrequency fields can cause any detectable change in stress-related gene expression.

研究の種別:

研究助成

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