研究のタイプ: 医学/生物学の研究 (experimental study)

[無線装置からの2.45GHz放射によるラット血液中の酸化ストレスに対するセレンおよびL-カルニチンの効果] med./bio.

Effects of Selenium and L-Carnitine on Oxidative Stress in Blood of Rat Induced by 2.45-GHz Radiation from Wireless Devices.

掲載誌: Biol Trace Elem Res 2009; 132 (1-3): 153-163

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研究目的(著者による)

To study the effects of 2.45 GHz electromagnetic field exposure on oxidant-antioxidant changes in rat blood and the possible protective effects of a L-carnitine and selenium.

詳細情報

30 male rats were divided into five groups: 1) cage control; 2) sham exposure; 3) 2.45 GHz exposure; 4) 2.45 GHz exposure + selenium; 5) 2.45 GHz exposure + L-carnitine. The first dose of selenium and L-carnitine was administered 24 h before exposure.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.45 GHz
Modulation type: pulsed
ばく露時間: continuous for 1 h/day on 28 days

General information

rats were treated in five groups: i) control ii) sham exposure iii) EMF exposure iv) EMF exposure + selenium v) EMF exposure + L-carnitine

ばく露1

主たる特性
周波数 2.45 GHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 1 h/day on 28 days
Modulation
Modulation type pulsed
Repetition frequency 217 Hz
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 antenna placed in the center of a round table that held 6 PVC cylinder containers (15 cm x 5 cm) for the rats so that the rats' noses were close to the antenna; exposure system kept in a Faraday cage
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電界強度 45.5346 V/m maximum 測定値 - -
電界強度 11.0705 V/m average over time 測定値 - -
SAR 0.1 W/kg - - whole body at 11 V/m
電力 2 W maximum - - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

The lipid peroxidation levels in plasma and erythrocytes were significantly higher in the exposure (group 3) than in the control groups (group 1 and 2), although the reduced glutathione and glutathione peroxidase values were slightly lower in erythrocytes of the exposure group compared to the control groups.
The data showed reduced erythrocyte glutathione levels in the exposure group compared to group 5 (exposure + L-carnitine). Erythrocyte glutathione peroxidase enzyme activity in sham exposure group, exposure group, and "exposure + selenium" group (group 4) were lower than in group 5 (exposure + L-carnitine).
The authors conclude, that 2.45 GHz electromagnetic field exposure caused oxidative stress in blood of rats. L-carnitine seems to have protective effects on the 2.45-GHz-induced blood toxicity. Selenium has no effect on the investigated values.

研究の種別:

研究助成

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