研究のタイプ: 医学/生物学の研究 (experimental study)

[セレンとL-カルニチンは無線装置からの2.45GHz放射によるラット心臓での酸化ストレスを低減する] med./bio.

Selenium and L-Carnitine Reduce Oxidative Stress in the Heart of Rat Induced by 2.45-GHz Radiation from Wireless Devices.

掲載誌: Biol Trace Elem Res 2011; 143 (3): 1640-1650

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研究目的(著者による)

To study the effects of 2.45 GHz electromagnetic field exposure on oxidant-antioxidant changes in the heart of rats and the possible protective effects of a L-carnitine and selenium.

詳細情報

30 male rats were divided into five groups: 1) cage control; 2) sham exposure; 3) 2.45 GHz exposure; 4) 2.45 GHz exposure + selenium (injection of 1.5 mg/kg/day); 5) 2.45 GHz exposure + L-carnitine (injection of 1.5 mg/kg/day). The first dose of selenium and L-carnitine was administered 24 h before exposure.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.45 GHz
Modulation type: pulsed
ばく露時間: continuous for 1 h/day on 28 days
  • 電力: 2 W maximum
  • 電界強度: 11 V/m spatial average
  • SAR: 0.1 W/kg average over mass (whole body) (at E = 11 V/m)
  • 電界強度: 45.5 V/m maximum
  • SAR: 2.4 W/kg maximum (whole body) (at E = 45.5 V/m d: bei)

General information

rats were treated in five groups: i) cage control ii) sham exposure iii) EMF exposure iv) EMF exposure + intraperitoneal injections of sodium selenite at a dose of 1.5 mg/kg/day v) EMF exposure + intraperitoneal injections of L-carnitine at a dose of 1.5 mg/kg/day

ばく露1

主たる特性
周波数 2.45 GHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 1 h/day on 28 days
Modulation
Modulation type pulsed
Repetition frequency 217 Hz
ばく露装置
ばく露の発生源/構造
  • half-wave dipole antenna
ばく露装置の詳細 rats placed in individual 15 cm x 5 cm PVC containers, arranged on a Plexiglas base in a circle round the antenna with the rats' noses close to it; exposure system placed in a Faraday cage
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電力 2 W maximum - - -
電界強度 11 V/m spatial average 測定値 - -
SAR 0.1 W/kg average over mass 計算値 whole body at E = 11 V/m
電界強度 45.5 V/m maximum 測定値 - -
SAR 2.4 W/kg maximum 計算値 whole body at E = 45.5 V/m d: bei

Reference articles

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

The lipid peroxidation levels were higher in the exposed group than in the cage control and sham exposed group. The lipid peroxidation levels in the irradiated animals treated with selenium and L -carnitine were lower than in those that were only exposed to 2.45 GHz irradiation.
The concentrations of vitamin A, vitamin C, and vitamin E were lower in the exposed-only group relative to cage control and sham exposed group, but their concentrations were increased in the exposed groups treated with selenium- and L-carnitine. The enzyme activity of glutathione peroxidase was higher in the selenium-treated group than in the animals that were exposed to the electromagnetic field but received no treatment. The glutathione and beta-carotene concentrations did not change in any of the groups.
In conclusion, 2.45 GHz electromagnetic field exposure caused oxidative stress in the heart of rats. There was a protective effect of selenium and L-carnitine.

研究の種別:

研究助成

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