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To investigate the effect of Ginkgo biloba extracts on mobile phone induced oxidative stress in brain tissue of rats.
Ginkgo extracts were feed to rats as dry powder. Specific metabolites such as malondialdehyde and nitric oxide (NO) and a broad variety of enzymes involved in antioxidative metabolism were investigated.
|ばく露時間||repeated daily exposure, 1 h/day for 7 days|
|チャンバの詳細||The exposure system was based on the reference article with some modifications. It consisted of six round ventilated tubes mounted circularly and two (?) mobile phones in the middle on top of them.|
|ばく露装置の詳細||Rats were confined in the tubes with their heads directed towards the antennas of the mobile phones. Mobile phones were activated by calling each other.|
|Additional information||Rats were divided into four exposure groups: EMR, EMR + Gb (Gingko biloba), Gb only, and controls. Control and Gb only groups were subjected to the same conditions except that the mobile phones were turned off.|
The three main outcomes of this study on rat brain can be resumed as followed:
1) mobile phones can induce oxidative damage. This is shown by increased levels of malondialdehyde, nitric oxide, xanthine oxidase, and adenosine deaminase.
2) Alterations in brain are histopathologically detectable.
3) Ginkgo biloba extracts act as a free radical scavenger agent and prevents oxidative damage and histopathological changes.