研究のタイプ: 医学/生物学の研究 (experimental study)

[ラット脳での酸化的バランスに対する超低周波磁界の影響] med./bio.

Effects of extremely low frequency magnetic field on oxidative balance in brain of rats.

掲載誌: J Physiol Pharmacol 2011; 62 (6): 657-661

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研究目的(著者による)

To study the effect of extremely low frequency magnetic fields most frequently used in magnetotherapy on reactive oxygen species generation in brain tissue of rats depending on the time of exposure.

詳細情報

30 animals were divided into one sham exposure group (n=10) and two exposure groups (each n=10; two different exposure durations: 30 min/day and 60 min/day).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 40 Hz
ばく露時間: 30 min/day (group ii) respectively 60 min/day (group iii) for 10 days between 7 a.m. and 10 a.m.

General information

30 rats were divided into three groups of 10 animals each: i) control group ii) and iii) experimental groups with different exposure duration

ばく露1

主たる特性
周波数 40 Hz
タイプ
  • magnetic field
波形
  • rectangular
ばく露時間 30 min/day (group ii) respectively 60 min/day (group iii) for 10 days between 7 a.m. and 10 a.m.
ばく露装置
ばく露の発生源/構造
  • apparatus used in magnetotherapy (MAGNETRONIK MF-10)
ばく露装置の詳細 rats in plastic containers were placed inside an applicator being part of the set for magnetotherapy
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
磁束密度 7 mT - - - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

Extremely low frequency magnetic fields of 7 mT, 40 Hz, 30 min/day for 10 days caused a significant increase in lipid peroxidation and insignificant increases in hydrogen peroxide and free sulfhydryl groups as well as an insignificant decrease in the total protein content (as compared with the control group).
The same extremely low frequency magnetic fields but applied for 60 min/day caused insignificant increases in lipid peroxidation and hydrogen peroxide as well as significant increases in free sulfhydryl groups and protein concentration in the brain homogenates (as compared with the control group).
The effect of extremely low frequency magnetic field irradiation on oxidative stress parameters depended on the duration of magnetic field exposure.

研究の種別:

研究助成

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