研究のタイプ: 医学/生物学の研究 (experimental study)

[酸化還元の変化を介するアポトーシスを磁界は防護する] med./bio.

Magnetic fields protect from apoptosis via redox alteration.

掲載誌: Ann N Y Acad Sci 2006; 1090: 59-68

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研究目的(著者による)

This in vitro study was performed to investigate the effects of a static magnetic field and an extremely low frequency magnetic field on intracellular oxidation-reduction, and the eventual relationship between magnetic field exposure, oxidative alteration, and apoptosis in human cancer cells.

詳細情報

In a previous study (publication 300) the exposure of the same cell line to a static magnetic field showed a decrease in apoptosis by increasing magnetic flux density. Here, the influence of magnetic field exposure through intracellular oxidation-reduction on apoptosis should be examined.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1:
ばく露時間: 2 h, 4 h, 72 h
ばく露2:
  • DC/static
ばく露時間: 2 h, 4 h, 72 h

ばく露1

主たる特性
周波数
タイプ
  • magnetic field
ばく露時間 2 h, 4 h, 72 h
Additional information for further information see reference article
ばく露装置
ばく露の発生源/構造
  • Faraday cage
ばく露装置の詳細 cell cultures exposed to magneic field inside the Faraday cage
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
磁束密度 0.07 mT minimum 測定値 - -
磁束密度 0.1 mT maximum 測定値 - -

ばく露2

主たる特性
周波数
  • DC/static
タイプ
  • magnetic field
ばく露時間 2 h, 4 h, 72 h
ばく露装置
ばく露の発生源/構造
  • magnets consisting of metal magnetic disks
ばく露装置の詳細 magnets were placed under the culture petri dish
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
磁束密度 0.6 mT - 計算値 - -

Reference articles

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

The static magnetic field caused a strong increase of reactive oxygen species. After 2 hours of magnetic field exposure a significant decrease of intracellular glutathione levels was found and maintained thereafter, up to 72 hours.
The extremely low frequency magnetic field significantly decreased intracellular glutathione levels starting from a threshold at 0.09 mT.
Exposure to extremely low frequency magnetic field revealed an anti-apoptotic effect. The treshold for the anti-apoptotic effect corresponded with the treshold necessary to induce oxidation-reduction imbalance. Apoptosis was not affected by the exposure to extremely low frequency magnetic field in cells artificially deprived of glutathione.
The extremely low frequency magnetic field and the static magnetic field seem to exert a similar effect in terms of apoptosis, but they differ clearly in their thresholds: 0.6 mT for the static magnetic field and 0.09 mT for the extremely low frequency magnetic field.

研究の種別:

研究助成

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