研究のタイプ: 医学/生物学の研究 (experimental study)

[培養ヒト細胞における1800MHz GSM無線周波ばく露および化学的突然変異原の共遺伝毒性の評価] med./bio.

Evaluation of the co-genotoxic effects of 1800 MHz GSM radiofrequency exposure and a chemical mutagen in cultured human cells.

掲載誌: CR physique 2010; 11 (9-10): 613-621

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研究目的(著者による)

To study the effect of a 1800 MHz radiofrequency GSM signal combined with a known chemical mutagen (4-nitroquinoline-N-oxide: 4NQO) on human cells.

詳細情報

No heating of the cell cultures was detected during exposure. Additional experiments were performed at 37, 39, 41 or 43°C (2 h, with 4NQO).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 1,800 MHz
Modulation type: pulsed
ばく露時間: continuous for 2 h

General information

cells were treated in four groups: i) sham exposure ii) EMF exposure iii) 1.8 µM 4NQO (4-nitroquinoline-N-oxide) + sham exposure iv) 1.8 µM 4NQO + EMF exposure

ばく露1

主たる特性
周波数 1,800 MHz
タイプ
  • electromagnetic field
特性
  • far field
ばく露時間 continuous for 2 h
Modulation
Modulation type pulsed
Duty cycle 12.5 %
Repetition frequency 217 Hz
ばく露装置
ばく露の発生源/構造
Distance between exposed object and exposure source 1 m
チャンバの詳細 three identical exposure chambers used - two for simultaneous exposures and one for sham exposure
ばく露装置の詳細 cells placed in Petri dishes inside thermoregulated Plexiglas incubators which were slowly rotated and positioned each inside an anechoic chamber; temperature inside the incubator 37°C; layer of small glass balls with a diameter of 1.5 mm placed inside the Petri dishes for efficient heat conduction; rectangular horn antenna positioned above the incubator;
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
SAR 2 W/kg - - - -
SAR 4 W/kg - - - -
SAR 8 W/kg - - - -
SAR 16 W/kg - - - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

The exposure of cells to electromagnetic fields with SARs of 2 to 16 W/kg did not increase the DNA damage induced by 4NQO, whereas the number of DNA strand breaks increased with a temperature rise of at least 4 °C. In conclusion, no co-genotoxic effect of radiofrequency electromagnetic field exposure was found at levels of exposure that did not induce heating.

研究の種別:

研究助成

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