研究のタイプ: 疫学研究 (observational study)

[神経膠腫に対する携帯電話およびコードレス電話のリスク:スウェーデンでの1997-2003年および2007-2009年における症例対照研究のプール分析] epidem.

Mobile phone and cordless phone use and the risk for glioma - Analysis of pooled case-control studies in Sweden, 1997-2003 and 2007-2009.

掲載誌: Pathophysiology 2015; 22 (1): 1-13

この論文は、著者らがスウェーデンで過去に行った、1997-2003年および2007-2009年にそれぞれ診断された悪性脳腫瘍患者を対象とする症例対照研究2件をプール分析した。診断時年齢はそれぞれ、20-80歳および18-75歳である。症例は1498人(参加率89%)、人口ベースで性別と年齢をマッチさせて選出された対照は3530人(参加率87%)。ばく露情報は質問紙によった。結果として、側頭葉神経膠腫において最も高いリスク推定値を得た;携帯電話またはコードレス電話の使用開始年齢が20歳以前の人での神経膠腫オッズ比は、使用開始年齢がそれ以降の人に比べて高かった、などを報告している。

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研究の目的(著者による)

A pooled analysis of case-control studies on glioma and use of mobile phones and cordless phones was conducted in Sweden.

詳細情報

Following studies are included: The first case-control study covering the period 1997-2000 was published in the publications Hardell et al (2002) and Hardell et al (2003). The second study covering the period 2000-2003 was published in Hardell et al (2005) concerning benign brain tumors and in Hardell et al (2006) concerning malignant brain tumors. A pooled analysis of these studies is published in Hardell et al (2006). The new case-control study on brain tumors was conducted in the period 2007-2009. The results of this new study on meningioma are published in Carlberg et al (2013). The results of the pooled analysis for acoustic neuroma, 1997-2003 and 2007-2009, is available in the publication Hardell et al (2013).

影響評価項目/リスク推定のタイプ

リスク推定のタイプ: (オッズ比(OR))

ばく露

ばく露評価

ばく露集団

グループ 説明
参照集団 1 unexposed
集団 2 analog mobile phone > 1 year latency period
集団 3 analog mobile phone > 1- to 5-year latency period
集団 4 analog mobile phone > 5- to 10-year latency period
集団 5 analog mobile phone > 10- to 15-year latency period
集団 6 analog mobile phone > 15- to 20-year latency period
集団 7 analog mobile phone > 20- to 25- year latency period
集団 8 analog mobile phone > 25 year latency period
集団 9 digital (2G) mobile phone > 1 year latency period
集団 10 digital (2G) mobile phone > 1- to 5-year latency period
集団 11 digital (2G) mobile phone > 5- to 10-year latency period
集団 12 digital (2G) mobile phone > 10- to 15-year latency period
集団 13 digital (2G) mobile phone > 15- to 20-year latency period
集団 14 digital (3G) mobile phone > 1 year latency period
集団 15 digital (3G) mobile phone > 1- to 5-year latency period
集団 16 digital (3G) mobile phone > 5- to 10-year latency period
集団 17 analog + digital mobile phone > 1 year latency period
集団 18 analog + digital mobile phone > 1- to 5-year latency period
集団 19 analog + digital mobile phone > 5- to 10-year latency period
集団 20 analog + digital mobile phone > 10- to 15-year latency period
集団 21 analog + digital mobile phone > 15- to 20-year latency period
集団 22 analog + digital mobile phone > 20-to 25-year latency period
集団 23 analog + digital mobile phone > 25 -year latency period
集団 24 cordless phone > 1 year latency period
集団 25 cordless phone > 1- to 5-year latency period
集団 26 cordless phone > 5- to 10-year latency period
集団 27 cordless phone > 10- to 15-year latency period
集団 28 cordless phone > 15- to 20-year latency period
集団 29 cordless phone > 20- to 25-year latency period
集団 30 digital phone (2G, 3G and/or cordless phone) > 1 year latency period
集団 31 digital phone (2G, 3G and/or cordless phone) > 1- to 5-year latency period
集団 32 digital phone (2G, 3G and/or cordless phone) > 5- to 10-year latency period
集団 33 digital phone (2G, 3G and/or cordless phone) > 10- to 15-year latency period
集団 34 digital phone (2G, 3G and/or cordless phone) > 10- to 15-year latency period
集団 35 digital phone (2G, 3G and/or cordless phone) > 20- to 25- year latency period
集団 36 mobile phone + cordless phone > 1 year latency period
集団 37 mobile phone + cordless phone > 1- to 5-year latency period
集団 38 mobile phone + cordless phone > 5- to 10-year latency period
集団 39 mobile phone + cordless phone > 10- to 15-year latency period
集団 40 mobile phone + cordless phone > 15- to 20-year latency period
集団 41 mobile phone + cordless phone > 20- to 25-year latency period
集団 42 mobile phone + cordless phone > 20-year latency period

調査対象集団

症例集団

対照集団

調査規模

症例 対照
適格者 1,691 4,038
参加者 1,498 3,530
参加率 89 % 87 %
その他:

1380 patients with glioma

統計学的分析方法: (調整: )

結論(著者による)

Mobile phone use increased the risk of glioma (group 17: OR 1.3, CI 1.1-1.6), increasing to OR 3.0 (CI 1.7-5.2) in the > 25 year latency group. An increased risk was observed with the use of cordless phones (group 24: OR 1.4, CI 1.1-1.7), with highest risk in the >15-20 year latency group (group 28: OR 1.7, CI 1.1-2.5). The OR increased statistically significant both per 100 h of cumulative use (OR 1.011, CI 1.008-1.014), and per year of latency for mobile and cordless phone use (OR 1.032, CI 1.019-1.046). An increased risk was found for ipsilateral mobile phone use (OR 1.8, CI 1.4-2.2) and cordless phone use (OR 1.7, CI 1.3-2.1). First use of mobile before the age of 20 gave higher OR (OR 1.8, CI 1.2-2.8) for glioma than in later age groups (20-49 years: OR 1.3, CI 1.1-1.6; 50 years and older: OR 1.3, KI 1.1-1.6); similar results were observed for cordless phone use.
The authors conclude that this pooled analysis gives further support that mobile phone and cordless phone use increases the risk for glioma.

研究助成

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