Studientyp:
Epidemiologische Studie
(Beobachtungsstudie)
Residential exposure to extremely low-frequency magnetic fields and risk of childhood leukaemia, CNS tumour and lymphoma in Denmark
epidem.
[Häusliche Exposition bei extrem niederfrequenten Magnetfeldern und das Risiko für Leukämie, ZNS-Tumor und Lymphom bei Kindern in Dänemark]
Von:
Pedersen C, Johansen C, Schüz J, Olsen JH, Raaschou-Nielsen O
Veröffentlicht in: Br J Cancer 2015; 113 (9): 1370-1374
Ziel der Studie (lt. Autor)
Weitere Details
Die Analysen wurden jeweils einzeln für jede Krebs-Art sowie für alle drei Krebs-Arten gemeinsam durchgeführt. Die relativen Risiken wurden für die Zeiträume von 1968-1986, 1987-2003 und für den gesamten Zeitraum 1968-2003 bestimmt.
Endpunkt/Art der Risikoabschätzung
Art der Abschätzung:
(relatives Risiko (RR))
Exposition
Abschätzung
- Berechnung: magnetische Flussdichte basierend auf der Entfernung der Wohnung zur nächsten Hochspannungs-Einrichtung unter Berücksichtigung der Leitungs-Kategorie, Masten-Art, Anordnung der Phasen, Stromfluss in der Leitung und Daten der Errichtung und des Umbaus
Expositionsgruppen
|
Gruppe
|
Charakteristik
|
|
Referenzgruppe 1
|
magnetische Flussdichte: < 0,1 µT
|
|
Gruppe 2
|
magnetische Flussdichte: 0,1 - 0,39 µT
|
|
Gruppe 3
|
magnetische Flussdichte: ≥ 0,4 µT
|
Population
-
Gruppe:
-
Alter:
0–14 Jahre
-
Beobachtungszeitraum:
1968 - 2003
-
Studienort:
Dänemark
Fallgruppe
Kontrollgruppe
- in Dänemark geborene Kinder, die ohne bisherige Krebs-Diagnose in Dänemark lebten
-
Auswahl:
-
Matching:
Studiengröße
|
Fälle |
Kontrollen |
| Anzahl geeignet |
3.277 |
9.129 |
Statistische Analysemethode:
- konditionale logistische Regression
Ergebnisse (lt. Autor)
Im gesamten Zeitraum von 1968-2003 waren nur 11 Fälle bei einer magnetischen Flussdichte von mehr als 0,4 µT zuhause exponiert (Gruppe 3).
Im Zeitraum von 1987-2003 betrug das relative Risiko 0,88 (KI 0,32-2,42) für die drei Tumor-Arten Leukämie, ZNS-Tumor und Lymphom gemeinsam bei einer Exposition ≥ 0,4 µT im Vergleich zu der Referenzgruppe (< 0,1 µT), während im gesamten Zeitraum (1968-2003) das relative Risiko 1,63 (KI 0,77-3,46) war.
Die Autoren schlussfolgerten, dass bei der Berücksichtigung der neueren Daten die vorherigen Ergebnisse eines fünf- bis sechsfach erhöhten Risikos für Leukämie, ZNS-Tumor und malignes Lymphom nicht bestätigt werden konnten. Für den gesamten Zeitraum stimmten die Ergebnisse zu Kinderleukämie mit den Ergebnissen von großen gepoolten Analysen, die relative Risiken zwischen 1,5 und 2 aufzeigen, überein.
Studie gefördert durch
-
CHILDREN with CANCER UK
-
Danish Cancer Society
-
Danish Energy Agency (Energistyrelsen)
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